Theoretical and Applied Genetics

, Volume 78, Issue 1, pp 93–96 | Cite as

Localization of the α2-macroglobulin gene and Lpm gene family on mink chromosome 9

  • V. I. Yermolaev
  • G. I. Karasik
  • T. M. Khlebodarova
  • N. M. Matveeva
  • M. R. Mullakandov
  • A. M. Nayakschin
  • T. V. Shumny
  • N. B. Rubtsov
  • O. L. Serov
  • O. K. Baranov
Originals
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Accepted:

Summary

Using cloned cDNA for human α2-macroglobulin (A2M) as a probe, mink-Chinese hamster hybrid cells were analysed. The results allowed us to assign a gene for A2M to mink chromosome 9. Breeding tests demonstrated that the Lpm-locus coding for other related α-macroglobulin protein and the gene for peptidase B (PEPB) are linked 11±3 cm apart. The PEPB gene is located on mink chromosome 9, and hence, the Lpw-locus is on the same mink chromosome. The relationship of the genetic systems controlling the isotypically different α-macroglobulins in mink serum are discussed.

Key words

α-Macroglobulin genes Chromosome mapping Mink 
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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • V. I. Yermolaev
    • 1
  • G. I. Karasik
    • 1
  • T. M. Khlebodarova
    • 1
  • N. M. Matveeva
    • 1
  • M. R. Mullakandov
    • 1
  • A. M. Nayakschin
    • 1
  • T. V. Shumny
    • 1
  • N. B. Rubtsov
    • 1
  • O. L. Serov
    • 1
  • O. K. Baranov
    • 1
  1. 1.Siberian DivisionInstitute of Cytology and Genetics, Academy of Sciences of the USSRNovosibirsk-90USSR

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