Calcified Tissue International

, Volume 57, Issue 2, pp 161–162

Vitamin D receptor gene polymorphism, bone mass, body size, and vitamin D receptor density

  • M. J. Barger-Lux
  • R. P. Heaney
  • J. Hayes
  • H. F. DeLuca
  • M. L. Johnson
  • G. Gong
Rapid Communication

Abstract

We determined vitamin D receptor (VDR) gene alleles (based on the BsmI restriction site polymorphism), duodenal mucosal receptor density, bone mass at spine and total body, and body size in 32 healthy premenopausal females. While we found no relationship between allele and receptor density in duodenal mucosa, bone mineral content (BMC) at both spine and total body was significantly associated with VDR gene alleles. BMC was highest for the bb allele, lowest for BB, and intermediate for Bb. A similar association was noted between allele and body size variables, particularly weight. When BMC was adjusted for body weight, the association with VDR polymorphism disappeared. The VDR gene polymorphism may be affecting bone mass not through classical nutritional mechanisms (e.g., intestinal calcium absorption), but through an influence on body size.

Key words

Bone mass Vitamin D receptor Body size VDR gene polymorphism 

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Copyright information

© Springer-Verlag New York Inc 1995

Authors and Affiliations

  • M. J. Barger-Lux
    • 1
  • R. P. Heaney
    • 1
  • J. Hayes
    • 2
  • H. F. DeLuca
    • 3
  • M. L. Johnson
    • 1
  • G. Gong
    • 1
  1. 1.Osteoporosis Research CenterCreighton UniversityOmaha
  2. 2.Garvan Institute of Medical ResearchSydneyAustralia
  3. 3.Department of BiochemistryUniversity of WisconsinMadison

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