Molecular and General Genetics MGG

, Volume 245, Issue 6, pp 787–790 | Cite as

Two new genes involved in signalling ambient pH in Aspergillus nidulans

  • Herbert N. ArstJr.
  • Elaine Bignell
  • Joan Tilburn
Short Communication


Two new genes, palH and palI, where mutations mimic the effects of acidic growth pH have been identified in Aspergillus nidulans. A palH mutation is phenotypically indistinguishable from mutations in the palA, palB, palC, and palF genes, whereas palI mutations differ only in that they allow some growth at pH 8. Mutations in palA, B, C, F, and H are epistatic to a palI mutation and the significance of this epistasis is discussed. Additionally, palE and palB mutations have been shown to be allelic. Thus, a total of six genes where mutations mimic acidic growth conditions has been identified.

Key words

Acidity-mimicking mutations Aspergillus nidulans pH regulation 


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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • Herbert N. ArstJr.
    • 1
  • Elaine Bignell
    • 1
  • Joan Tilburn
    • 1
  1. 1.Department of Infectious Diseases and BacteriologyRoyal Postgraduate Medical SchoolLondonEngland

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