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Diabetologia

, Volume 30, Issue 9, pp 713–718 | Cite as

Elevated serum uric acid — a facet of hyperinsulinaemia

  • M. Modan
  • H. Halkin
  • A. Karasik
  • A. Lusky
Originals

Summary

In a representative sample of the adult Jewish population in Israel (n=1016) excluding known diabetic patients and individuals on antihypertensive medications, serum uric acid showed a positive association with plasma insulin response (sum of 1- and 2-hour post glucose load levels) in both males (r=0.316, p<0.001) and females (r=0.236, p<0.001). This association remained statistically significant in both sexes (p<0.001) after accounting by multiple regression analysis for age and major correlates of serum uric acid, i.e. body mass index, glucose response (sum of 1- and 2-hour post load levels), systolic blood pressure and total plasma triglycerides. The net portion of the variance of serum uric acid attributable to insulin response was 12% in males and 8% in females, the total variance accountable by all these variables being 17% and 19% respectively. We conclude that elevated serum uric acid is a feature of hyperinsulinaemia/insulin resistance.

Key words

Serum uric acid hyperinsulinaemia Type 2 (non-insulin-dependent) diabetes impaired glucose tolerance hypertension obesity plasma triglycerides 

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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • M. Modan
    • 1
    • 2
  • H. Halkin
    • 1
    • 2
  • A. Karasik
    • 1
    • 2
  • A. Lusky
    • 1
    • 2
  1. 1.Department of Clinical EpidemiologyChaim Sheba Medical CenterTel Hashomer
  2. 2.Department of MedicineTel Aviv University Sackler School of MedicineIsrael

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