Calcified Tissue International

, Volume 51, Issue 6, pp 401–405 | Cite as

Calcium involvement in free radical effects

  • Rodolfo Bracci


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  1. 1.
    Kacew S, Reasor MJ (eds) (1984) Toxicology and the newborn. Elsevier Science Publishers BV, AmsterdamGoogle Scholar
  2. 2.
    Stern A (1989) Drug-induced oxidative denaturation in red blood cells. Semin Hematol 26:301–306Google Scholar
  3. 3.
    Saltman P (1989) Oxidative stress: a radical view. Semin Hematol 26:249–256Google Scholar
  4. 4.
    Biemond P, Swaak AJG, van Eijk HG, Koster JF (1988) Superoxide-dependent iron release from ferritin in inflammatory diseases. Free Rad Biol Med 4:185–198Google Scholar
  5. 5.
    Halliwell B, Gutteridge JMC (1986) Oxygen-free radicals and iron in relation to biology and medicine: some problems and concepts. Arch Biochem Biophys 246:501–514Google Scholar
  6. 6.
    Hassan HM, Fridovich I (1979) Intracellular production of superoxide radical and of hydrogen peroxide by redox active compounds. Arch Biochem Biophys 196:385–395Google Scholar
  7. 7.
    Canada AT, Calabrese EJ (1989) Superoxide dismutase: its role in xenobiotic detoxification. Pharmac Ther 44:285–295Google Scholar
  8. 8.
    Hong Y, Li CH, Burgess JR, Chang M, Salem A, Srikumar K, Reddy CC (1989) The role of selenium-dependent and seleniumindependent glutathione peroxidases in the formation of prostaglandin F2*. J Biol Chem 264:13793–13800Google Scholar
  9. 9.
    German JB, Hu ML (1990) Oxidant stress inhibits the endogenous production of lipoxygenase metabolites in rat lungs and fish gills. Free Rad Biol Med 8:441–448Google Scholar
  10. 10.
    Babior BM (1984) Oxidants from phagocytes: agents of defense and destruction. Blood 64:959–966Google Scholar
  11. 11.
    Malech HL, Gallin JI (1987) Neutrophils in human diseases. N Engl J Med 317:687–694Google Scholar
  12. 12.
    McCord JM (1985) Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 312:159–163Google Scholar
  13. 13.
    McCord JM, Fridovich I (1968) The reduction of cytochrome by milk xanthine oxidase. J Biol Chem 243:560–573Google Scholar
  14. 14.
    Fridovich I (1970) Quantitative aspects of the production of superoxide anion radical milk xanthine oxidase. J Biol Chem 245:4053–4057Google Scholar
  15. 15.
    Saugstad OD (1988) Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res 23:143–150Google Scholar
  16. 16.
    Goldberg B, Stern A, Peisach J (1976) The mechanism of superoxide anion generation by its interaction of phenylhydrazine with hemoglobin. J Biol Chem 251:3045–3051Google Scholar
  17. 17.
    Goldstein BD, McDonagh EM (1976) Spectrofluorescent detection of in vivo red cell lipid peroxidation in patients treated with diaminodiphenylsulfone. J Clin Invest 57:1302–1307Google Scholar
  18. 18.
    Van Der Zee J, Van Steveninck J, Koster JF, Dubbelman TMAR (1989) Inhibition of enzymes and oxidative damage of red blood cells induced by t-butylhydroperoxide-derived radicals. Biochim Biophys Acta 980:175–180Google Scholar
  19. 19.
    Arduini A, Stern A (1985) Spectrin degradation in intact red blood cells by phenylhydrazine. Biochem Pharmacol 34:4283–4289Google Scholar
  20. 20.
    Arduini A, Chen Z, Stern A (1986) Phenylhydrazine-induced changes in erythrocyte membrane surface lipid packing. Biochim Biophys Acta 862:65–71Google Scholar
  21. 21.
    Arese P, De Flora A (1990) Pathophysiology of hemolysis in glucose-6-phosphate dehydrogenase deficiency. Semin Hematol 27:1–40Google Scholar
  22. 22.
    Arduini A, Storto S, Belfiglio M (1989) Mechanism of spectrin degradation induced by phenylhydrazine in intact human erythrocytes. Biochem Biophys Acta 979:1–6Google Scholar
  23. 23.
    Snyder LM, Fortier NL, Trainor J, Jacobs J, Leb L, Lubin B, Chiu D, Shohet S, Mohandas N (1985) Effect of hydrogen peroxide exposure on normal human erythrocyte deformability, morphology, surface characteristics, and spectrin-hemoglobin cross-linking. J Clin Invest 76:1971–1977Google Scholar
  24. 24.
    Watanabe H, Kobayashi A, Yamamoto T, Suzuki S, Hayashi H, Yamazaki N (1990) Alterations of human erythrocyte membrane fluidity by oxygen-derived free radicals and calcium. Free Radic Biol Med 9:507–514Google Scholar
  25. 25.
    Okabe E, Hess ML, Oyama M, Ito H (1983) Characterization of free radial-mediated damage of canine cardiac sarcoplasmic reticulum. Arch Biochem Biophys 225:164–177Google Scholar
  26. 26.
    Varecka L, Carafoli E (1982) Vanadate-induced movements of Ca2+ and K+ in human red blood cells. J Biol Chem 257:7414–7421Google Scholar
  27. 27.
    Morelli A, Grasso M, Meloni T (1987) Favism: impairment of proteolytic systems in red blood cells. Blood 68:1753–1758Google Scholar
  28. 28.
    De Flora A, Morelli A, Grasso M (1987) Alterations of red blood cell proteolysis in favism. Biomed Biochim Acta 46:S184-S189Google Scholar
  29. 29.
    Low PS, Waugh SM, Zinke K (1985) The role of hemoglobin denaturation and band 3 clustering in red blood cell aging. Science 227:531–533Google Scholar
  30. 30.
    Bors W, Buettner GR, Michel C, Saran M (1988) Calcium in lipid peroxidation: Does calcium interact with superoxide? Arch Biochem Biophys 266:446–451Google Scholar
  31. 31.
    Higgins AJ, Blackburn KJ (1984) Prevention of reperfusion damage in working rat hearts by calcium antagonists and calmoduling antagonists. J Mol Cell Cardiol 16:427–438Google Scholar
  32. 32.
    Otani H, Engelman RM, Rousou JA et al (1989) Improvement of myocardial function by trifluoperazine, a calmodulin antagonist, during experimental acute coronary artery occlusion and reperfusion. J Thorac Cardiovasc Surg 97:267–274Google Scholar
  33. 33.
    Malech HL, Gallin JL (1987) Neutrophils in human diseases. N Engl J Med 317:687–694Google Scholar
  34. 34.
    Lehrer RI, Ganz T, Selsted ME, Babior BM, Curnutte JT (1988) Neutrophils and host defense. Ann Intern Med 109:127–142Google Scholar
  35. 35.
    Weiss SJ (1989) Tissue destruction by neutrophils. N Engl J Med 320:365–376Google Scholar
  36. 36.
    Morel F, Doussiere J, Vignais PV (1991) The superoxidegenerating oxidase of phagocytic cells. Physiological, molecular and pathological aspects. Eur J Biochem 201:523–546Google Scholar
  37. 37.
    Hallett MB, Davies EV, Campbell AK (1990) Cell Calcium 11: 655–663Google Scholar
  38. 38.
    Gallin JI, Fauci AS (eds) (1983) Advances in host defense mechanisms vol. 3. Chronic granulomatous disease. Raven Press, New YorkGoogle Scholar
  39. 39.
    Biemond P, Swaak AJG, Koster JF (1984) Protective factors against oxygen-free radicals and hydrogen peroxide in rheumatoid arthritis synovial fluid. Arthritis Rheum 27:760–765Google Scholar
  40. 40.
    Kleinveld HA, Swaak AJG, Hack CE, Koster JF (1989) Interactions between oxygen-free radicals and proteins. Scand J Rheumatol 18:341–352Google Scholar
  41. 41.
    Merry P, Winyard PG, Morris CJ, Grootveld M, Blake DR (1989) Oxygen-free radicals, inflammation, and synovitis: the current status. Ann Rheum Dis 48:864–870Google Scholar
  42. 42.
    Igari T, Kaneda H, Horiuchi S, Ono S (1982) A remarkable increase of superoxide dismutase activity in synovial fluid of patients with rheumatoid arthritis. Clin Orthop 162:282–287Google Scholar
  43. 43.
    Hong Y, Li CH, Burgess JR, Change M, Salem A, Srikumar K, Reddy CC (1989) The role of selenium-dependent and selenium-independent glutathione peroxidasess in the formation of prostaglandin F2α. J Biol Chem 264:13793–13800Google Scholar
  44. 44.
    Malech HL, Gallin JI (1987) Neutrophils in human diseases. N Engl J Med 317:687–694Google Scholar
  45. 45.
    Mundy GR, Roodman GD (1987) Osteoclast ontogeny and function. In: Peck VW (ed) Bone and mineral research. Elsevier/North Holland, New York, pp. 209–280Google Scholar
  46. 46.
    Nathan CF (1987) Secretory products of macrophages. J Clin Invest 79:319–326Google Scholar
  47. 47.
    Halliwell B, Gutteridge JMC (1985) Free radicals in biology and medicine. Clarendon Press, OxfordGoogle Scholar
  48. 48.
    Ross Garrett I, Boyce BF, Oreffo ROC, Bonewald L, Poser J, Mundy GR (1990) Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. J Clin Invest 85:632–639Google Scholar
  49. 49.
    Fallon M, Silverton S, Smith P, Moskal T, Constantinescu C, Feldman R, Golub E, Shapiro I (1986) The oxidative metabolism of isolated osteoclasts is regulated by calcitropic agents (abstract) J Bone Miner Res 1 (suppl 1)Google Scholar
  50. 50.
    Stock JL, Coderre JA, Levine PH (1984) Effects of calciumregulating hormones and drugs on monocyte chemiluminescence. J Clin Endocrinol Metab 55:956–960Google Scholar
  51. 51.
    Friedman J, Au WYW, Raisz LG (1968) Responses of fetal rat bone to thyrocalcitonin in tissue culture. Endocrinology 82:149–156Google Scholar
  52. 52.
    Ren W, Dziak R (1991) Effects of leukotrienes on osteoblastic cell proliferation. Calcif Tissue Int 49:197–201Google Scholar
  53. 53.
    Meghji S, Sandy JR, Scutt AM, Harvey W, Harris M (1988) Stimulation of bone resorption by lipoxygenase metabolites of arachidonic acid. Prostaglandins 36:139Google Scholar
  54. 54.
    Matsumoto H, Silverton SF, Debolt K, Shapiro IM (1991) Superoxide dismutase and catalase activities in the growth cartilage: relationship between oxidoreductase activity and chondrocyte maturation. J Bone Miner Res 6:569–574Google Scholar
  55. 55.
    Frank L, Sosenko IRS (1987) Development of lung antioxidant enzyme system in late gestation: possible implications for the prematurely born infant. J Pediatr 110:9–14Google Scholar
  56. 56.
    Demus-Oole A, Swierczewski E (1969) Glutathione peroxidase in rat liver during development. Biol Neonate 14:211–218Google Scholar
  57. 57.
    Mavelli I, Autuori F, Dini L, Spinedi A, Ciriolo MR, Rotilio G (1981) Correlation between superoxide dismutase, glutathione peroxidase and catalase in isolated rat hepatocytes during fetal development. Biochem Biophys Res Commun 102:911–916Google Scholar
  58. 58.
    Yoshioka T, Utsumi K, Sekiba K (1977) Superoxide dismutase activity and lipid peroxidation of the rat liver during development. Biol Neonate 32:147–153Google Scholar
  59. 59.
    Fryer AA, Hume R, Strange RC (1986) The development of glutathione S-transferase and glutathione peroxidase activities in human lung. Biochim Biophys Acta 883:448–453Google Scholar
  60. 60.
    Wright SW, Filer LJ Jr, Mason KE (1951) Vitamin E blood levels in premature and full-term infants. Pediatrics 7:386Google Scholar
  61. 61.
    Haga P (1981) Plasma vitamin E levels and vitamin E/*-lipoprotein relationships in small preterm infants during the early anemia of prematurity. Eur J Pediatr 136:143–147Google Scholar
  62. 62.
    Tanaka H, Mino M, Takeuchi T (1988) A nutritional evaluation of vitamin E status in very low birth weight infants with respect to changes in plasma and red blood cell tocopherol levels. J Nutr Sci Vitaminol 34:293–307Google Scholar
  63. 63.
    Gross RT, Bracci R, Rudolph N, Schroeder E, Kochen JA (1967) Hydrogen peroxide toxicity and detoxification in the erythrocytes of newborn infants. Blood 29:481–493Google Scholar
  64. 64.
    Rotilio G, Rigo A, Bracci R, Bagnoli F, Sargentini I, Brunori M (1977) Determination of red blood cell superoxide dismutase and glutathione peroxidase in newborns in relation to neonatal hemolysis. Clin Chim Acta 81:131–134Google Scholar
  65. 65.
    Bracci R, Buonocore G, Talluri B, Berni S (1988) Neonatal hyperbilirubinemia. Evidence for a role of the erythrocyte enzyme activities involved in the detoxification of oxygen radicals. Acta Paed Scand 77:349–356Google Scholar
  66. 66.
    Buonocore G, Berni S, Gioia D, Bracci R (1991) Characteristics and functional properties of red cells during the first days of life. Biol Neonate 60:137–144Google Scholar
  67. 67.
    Bracci R, Martini G, Buonocore G, Talluri B, Berni S, Ottaviani MF, Picchi MP, Casini A (1988) Changes in erythrocyte properties during the first hours of life: electron spin resonance of reacting sulfydryl groups. Pediatr Res 24:391–395Google Scholar
  68. 68.
    Shahal Y, Bauminger ER, Zmora E, Katz M, Mazor D, Horn S, Meyerstein N (1991) Oxidative stress in newborn erythrocytes. Pediatr Res 29:119–122Google Scholar
  69. 69.
    Winterbourn CC, Stern A (1987) Human red cells scavenge extracellular hydrogen peroxide and inhibit formation of hypochlorous acid and hydroxyl radical. J Clin Invest 80:1486–1491Google Scholar
  70. 70.
    Tanswell AK, Freeman BA (1984) Pulmonary antioxidant enzyme maturation in the fetal and neonatal rat. I. Developmental profiles. Pediatr Res 18:584–587Google Scholar
  71. 71.
    Tanswell AK, Freeman BA (1984) Pulmonary antioxidant enzyme maturation in the fetal and neonatal rat. II. The influence of maternal iron supplements upon fetal lung catalase activity. Pediatr Res 18:871–874Google Scholar
  72. 72.
    Tanswell AK, Tzaki MG, Byrne PJ (1986) Hormonal and local factors influence antioxidant enzyme activity of rat fetal lung cells in vitro. Exp. Lung Res. 11:49–59Google Scholar
  73. 73.
    Frank L, Lewis PL, Sosenko IRS (1985) Dexamethasone stimulation of fetal rat lung antioxidant enzyme activity in parallel with surfactant stimulation. Pediatrics 75:569–574Google Scholar
  74. 74.
    Buonocore G, Berni S, Bagnoli F, Gioia D, De Nisi G, Bracci R (1990) Erythrocyte antioxidant enzymatic system in preterm newborn. In: Bracci R, Bagnoli F, Buonocore G (eds) Intl Congr on Neonatal Hematology and Immunology, Siena April 22–24, 1990, p 48Google Scholar
  75. 75.
    Ahmad H, Medh RD, Singh SV, Caccuri AM, Ansari GAS, Awasthi YC (1989) Anionic glutathione S-transferases of human erythrocytes, placenta, and lung: evidence for structural differences. Enzyme 42:129–135Google Scholar
  76. 76.
    Toh N, Inoue T, Kuraya M, Tanaka H, Kimoto E (1987) Antioxidative activities of a reductant in the ultrafiltrate of human placental homogenate. Biol Res Pregn 8:47–52Google Scholar

Copyright information

© Springer-Verlag New York Inc 1992

Authors and Affiliations

  • Rodolfo Bracci
    • 1
  1. 1.Division of NeonatologyUniversity of SiennaSiennaItaly

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