Biochemical markers of nutrition in osteoporosis
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Summary
Thirty-six women with vertebral osteoporosis showed significantly decreased levels of biochemical markers of nutrition, transferrin (P<0.001), prealbumin (P<0.001), retinol binding-protein (P<0.001), and fibronectin (P<0.001), compared with 40 healthy women of similar age. Multiple regression analysis showed a significant (R2=0.509; P=0.0068) correlation between bone mineral content and biochemical markers of nutrition in the osteoporotic patients but not in the control group. These data suggest that postmenopausal osteoporosis may be associated with a nutritional deficiency.
Key words
Osteoporosis Nutrition Biochemical markers Crush fracture syndromePreview
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References
- 1.Benjamin DR (1989) Laboratory test and nutritional assessment. Pediatr Clin North Am 36:139–161PubMedGoogle Scholar
- 2.Mohan V, Snehalatha C, Bhattacharyya PK, Ramachandran A, Viswanathan M (1991) Nutritional profile of fibrocalculous pancreatic diabetes and primary forms of diabetes seen in southern India. Diabetes Res Clin Pract 11:203–207CrossRefPubMedGoogle Scholar
- 3.Mattox TW, Teasley-Strausburg KM (1991) Overview of biochemical markers used for nutrition support. DICP 25:265–271PubMedGoogle Scholar
- 4.Uderzo C, Rovelli A, Bonomi M, Fomia L, Pirovano L, Masera G (1991) Total parenteral nutrition and nutritional assessment and leukaemic children undergoing bone marrow transplantation. Eur J Cancer 27:758–762PubMedGoogle Scholar
- 5.Calloway CW (1987) Dietary effects on osteoporosis. JAMA 257:1652Google Scholar
- 6.Santora AC (1987) Role of nutrition and exercise in osteoporosis. Am J Med 82 (suppl 1B):73–79PubMedGoogle Scholar
- 7.Fleisch H (1988) Osteoporosis—a nutrition problem. Bibl Nutr Dieta 42:67–69PubMedGoogle Scholar
- 8.Rico H, Revilla M, Villa LF, Hernandez ER, Fernandez JP (1992) Crush fracture syndrome in senile osteoporosis. A nutritional consequence?. J Bone Miner Res 13:317–319Google Scholar
- 9.Avioli LV (1991) Calcium metabolism and osteoporosis in China, Japan, and Pacific Rim Communities, Calcif Tissue Int 48:149–150Google Scholar
- 10.Thomas AJ (1988) Osteoporosis. Lancet 1:1002PubMedGoogle Scholar
- 11.Strain JJ (1988) A reassessment of dietand osteoporosis—possible role for Cooper. Med Hypotheses, 27:333–338CrossRefPubMedGoogle Scholar
- 12.Silbergeld EK, Schwartz J, Mahaffey K (1988) Lead and osteoporosis: mobilization of lead from bone in postmenopausal women. Environ Res 47:79–94CrossRefPubMedGoogle Scholar
- 13.Trimmer E (1988) Osteoporosis. Lancet 1:177Google Scholar
- 14.Reginster JY, Strause L, Deroisy R, Lecart MP, Saltman P, Franchimont P (1989) Preliminary report of decreased serum magnesium in postmenopausal osteoporosis. Magnesium 8:106–109PubMedGoogle Scholar
- 15.Rico H (1991) Minerals and osteoporosis. Osteoporosis Int 2:20–25CrossRefGoogle Scholar
- 16.Cooper C, Mclaren M, Wood PJ, Coulton L, Kanis JA (1989) Indices of calcium metabolism in women with hip fractures. Bone Miner 5:193–200CrossRefPubMedGoogle Scholar
- 17.Hordon LD, Peacock M (1990) Osteomalacia and osteoporosis in femoral neck fracture. Bone Miner 11:247–259PubMedGoogle Scholar
- 18.Orwoll ES, Weigel RM, Oviatt SK, Meier DE, McClung MR (1987) Serum protein concentrations and bone mineral content in aging normal men. Am J Clin Nutr 46:614–621PubMedGoogle Scholar
- 19.Epstein E, Kiechle FL, Artiss JD, Zak B (1986) The clinical use of alkaline phosphatase enzymes. Clin Lab Med 6:491–505PubMedGoogle Scholar
- 20.Rask L, Anundi H, Bohme J, Eriksson U, Fredriksson A, Nilsson SF, Ronne H, Vahlquist A, Peterson PA (1980) The retinol binding protein. Scand J Clin Lab Invest (suppl) 154:45–61Google Scholar
- 21.Bates J, McClain CJ (1981) The effects of severe zinc deficiency on serum levels of albumin: transferrin and prealbumin in man. Am J Clin Nutr 34:1655–1660PubMedGoogle Scholar
- 22.Fernandez-Madrid F, Prasad AS, Oberleas D (1973) Effect of zinc deficiency on nucleic acids, collagen, and non-collagenous protein of connective tissue. J Lab Clin Med 82:951–961PubMedGoogle Scholar
- 23.Delacoux E, Evstigneeff TH, Leclerq M, Rettori MC, Delons S, Naret C, Blanchet-Bardon C (1984) Skin disorders and vitamin A metabolism disturbances in chronic dialysis patients: the role of zinc, retinol binding protein, retinol and retinoic acid. Clin Chim Acta 137:283–289CrossRefPubMedGoogle Scholar
- 24.Atik OS (1983) Zinc and senile osteoporosis. J Am Geriatr Soc 31:790–791PubMedGoogle Scholar
- 25.Ohry A, Shemesh Y, Zak R, Herberg M (1980) Zinc and osteoporosis in patients with spinal cord injury. Paraplegia 18:174–180PubMedGoogle Scholar
- 26.Herzberg M, Foldes J, Steinberg R, Menczel J (1990) Zinc excretion in osteoporotic women. J Bone Miner Res 5:251–257PubMedGoogle Scholar
- 27.Angus RM, Sambrook PN, Pocock NA, Eisman JA (1988) Dietary intake and bone mineral density. Bone Miner 4:265–277PubMedGoogle Scholar
- 28.Freudenheim JL, Johnson NE, Smith EL (1986) Relationships between usual nutrient intake and bone mineral content of women 35–65 years of age: longitudinal and cross-sectional analysis. Am J Clin Nutr 44:863–876PubMedGoogle Scholar
- 29.Yamaguchi M, Kitajima T (1991) Effect of estrogen on bone metabolism in tissue culture: enhancement of the steroid effect by zinc. Res Exp Med 191:145–154Google Scholar
- 30.Helliwell M, Coombes EJ, Moody BJ, Bastone GF, Robertson JC (1984) Nutritional status in patients with rheumatoid arthritis. Ann Rheum Dis 43:386–390PubMedGoogle Scholar
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