Analysis of the breakpoints in translocation (15;17) Observed in 4 patients with acute promyelocytic leukemia
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Four patients with acute promyelocytic leukemia (APL) and the chromosomal translocation t(15;17) are described in detail. One of the patients presented with the microgranular variant form of APL and the standard translocation. Another patient is the third reported case with isochromosome formation of the 17q- derivative. Use of high resolution culture technique with methotrexate treatment allowed us to define the break-points at 15q2200 and 17q12.
KeywordsAcute Myeloid Leukemia Acute Promyelocytic Leukemia Acridine Orange Cytogenet Cell Acute Nonlymphocytic Leukemia
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- First International Workshop on Chromosomes in Leukemia, Helsinki (1977) General report. Cytogenet Cell Genet 19: 321–325Google Scholar
- Löwenberg B, Gijn J van, Prins E, Polderman AM (1982) Fatal cerebral toxoplasmosis in a bone marrow transplant recipient with leukemia. Transplantation (in press)Google Scholar
- Second International Workshop on Chromosomes in Leukemia, 1979 (1980) Chromosomes in acute promyelocytic leukemia. Cancer Genet Cytogenet 2: 103–107Google Scholar