Human Genetics

, Volume 61, Issue 3, pp 223–227 | Cite as

Analysis of the breakpoints in translocation (15;17) Observed in 4 patients with acute promyelocytic leukemia

  • A. Hagemeijer
  • B. Löwenberg
  • J. Abels
Original Invesigations


Four patients with acute promyelocytic leukemia (APL) and the chromosomal translocation t(15;17) are described in detail. One of the patients presented with the microgranular variant form of APL and the standard translocation. Another patient is the third reported case with isochromosome formation of the 17q- derivative. Use of high resolution culture technique with methotrexate treatment allowed us to define the break-points at 15q2200 and 17q12.


Acute Myeloid Leukemia Acute Promyelocytic Leukemia Acridine Orange Cytogenet Cell Acute Nonlymphocytic Leukemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C (FAB cooperative group) (1976) Proposals for the classification of the acute leukaemias. Br J Haematol 33: 451–458CrossRefPubMedGoogle Scholar
  2. Bennett JM, Catovsky D, Daniel MT, Flandrin G Galton DAG, Gralnick HR, Sultan C (FAB cooperative group) (1980) A variant form of hypergranular promyelocytic leukaemia (M3). Br J Haematol 44: 169–170CrossRefPubMedGoogle Scholar
  3. Berger R, Bernheim A, Daniel MT, Valensi F, Flandrin G, Jean Bernard (1979) Translocation t(15;17), leucémie aiguë promyélocytaire et non promyélocytaire. Nouv Rev Fr Hematol 21: 117–131PubMedGoogle Scholar
  4. De La Chapelle A, Knuutila S, Elonen E, Vuopio P (1981) Chromosomal abnormalities in acute promyelocytic leukaemia Scand J Haematol 26: 57–60CrossRefPubMedGoogle Scholar
  5. First International Workshop on Chromosomes in Leukemia, Helsinki (1977) General report. Cytogenet Cell Genet 19: 321–325Google Scholar
  6. Golomb HM, Rowley JD, Vardiman JW, Testa JR, Butler A (1980) “Microgranular” acute promyelocytic leukemia: A distinct clinical, ultrastructural and cytogenetic entity. Blood 55 253–259PubMedGoogle Scholar
  7. Hagemeijer A, Smit EME, Bootsma D (1979) Improved identification of chromosomes of leukemic cells in methotrexate-treated cultures. Cytogenet Cell Genet 23: 208–212CrossRefPubMedGoogle Scholar
  8. Hagemeijer A, Hählen K, Abels J (1981) Cytogenetic follow-up of patients with nonlymphocytic leukemia. II. Acute nonlymphocytic leukemia. Cancer Genet Cytogenet 3: 109–124CrossRefPubMedGoogle Scholar
  9. International System for Human Cytogenetic Nomenclature (ISCN) (1978) Cytogenet Cell Genet 21: 309–404CrossRefGoogle Scholar
  10. Kondo K, Sasaki M (1979) Cytogenetic studies in four cases of acute promyelocytic leukemia (APL) Cancer Genet Cytogenet 1: 131–138CrossRefGoogle Scholar
  11. Löwenberg B, Gijn J van, Prins E, Polderman AM (1982) Fatal cerebral toxoplasmosis in a bone marrow transplant recipient with leukemia. Transplantation (in press)Google Scholar
  12. Rowley JD, Golomb HM, Vardiman J, Fukuhara S, Dougherty C, Potter D (1977) Further evidence for a non-random chromosomal abnormality in acute promyelocytic leukemia. Int J Cancer 20: 869–872CrossRefPubMedGoogle Scholar
  13. Scheres JMJC, Hustinx TWJ, Vaan GAM de, Rutten FJ (1978) 15/17 Translocation in acute promyelocytic leukaemia. Hum Genet 43: 115–117CrossRefPubMedGoogle Scholar
  14. Second International Workshop on Chromosomes in Leukemia, 1979 (1980) Chromosomes in acute promyelocytic leukemia. Cancer Genet Cytogenet 2: 103–107Google Scholar
  15. Testa JR, Golomb HM, Rowley JD, Vardiman JW Sweet DL Jr (1978) Hypergranular promyelocytic leukemia (APL): Cytogenetic and ultrastructural specificity. Blood 52: 272–280PubMedGoogle Scholar
  16. Van den Berghe H, Louwagie A, Broeckaert-Van Orshoven A, David G, Verwilghen R, Michaux JL, Sokal G (1979) Chromosome abnormalities in acute promyelocytic leukemia (APL) Cancer 43: 558–562CrossRefGoogle Scholar
  17. Yunis JJ, Bloomfield CD, Ensrud K (1981) All patients with acute nonlymphocytic leukemia may have a chromosomal defect. N Engl J Med 305: 135–139CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • A. Hagemeijer
    • 1
  • B. Löwenberg
    • 2
    • 3
  • J. Abels
    • 2
  1. 1.Department of Cell Biology and GeneticsErasmus UniversityRotterdamThe Netherlands
  2. 2.Institute of HematologyErasmus UniversityRotterdamThe Netherlands
  3. 3.Department of Hematology of the Rotterdam Radiotherapeutic InstituteRotterdamThe Netherlands

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