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Human Genetics

, Volume 61, Issue 3, pp 223–227 | Cite as

Analysis of the breakpoints in translocation (15;17) Observed in 4 patients with acute promyelocytic leukemia

  • A. Hagemeijer
  • B. Löwenberg
  • J. Abels
Original Invesigations

Summary

Four patients with acute promyelocytic leukemia (APL) and the chromosomal translocation t(15;17) are described in detail. One of the patients presented with the microgranular variant form of APL and the standard translocation. Another patient is the third reported case with isochromosome formation of the 17q- derivative. Use of high resolution culture technique with methotrexate treatment allowed us to define the break-points at 15q2200 and 17q12.

Keywords

Acute Myeloid Leukemia Acute Promyelocytic Leukemia Acridine Orange Cytogenet Cell Acute Nonlymphocytic Leukemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • A. Hagemeijer
    • 1
  • B. Löwenberg
    • 2
    • 3
  • J. Abels
    • 2
  1. 1.Department of Cell Biology and GeneticsErasmus UniversityRotterdamThe Netherlands
  2. 2.Institute of HematologyErasmus UniversityRotterdamThe Netherlands
  3. 3.Department of Hematology of the Rotterdam Radiotherapeutic InstituteRotterdamThe Netherlands

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