Human Genetics

, Volume 71, Issue 1, pp 45–48

Genetic polymorphism of human factor I (C3b inactivator)

  • S. Nakamura
  • K. Abe
Original Investigations

DOI: 10.1007/BF00295667

Cite this article as:
Nakamura, S. & Abe, K. Hum Genet (1985) 71: 45. doi:10.1007/BF00295667


Genetic polymorphism of human factor I (C3b inactivator) has been described using polyacrylamide gel isoelectric focusing electrophoresis of neuraminidase-treated EDTA plasma samples followed by electrophoretic blotting technique. In 435 individuals three different common patterns were observed, and these were controlled by two common alleles at a single locus. The results of typing family material confirmed autosomal codominant Mendelian inheritance. Two common alleles were designated FI*B and FI*A, and gene frequencies were estimated to be 0.8931 and 0.1069 for FI*B and FI*A, respectively. The distribution of phenotypes fitted the Hardy-Weinberg equilibrium. Linkage studies failed to show close linkage between factor I and the major histocompatibility complex.

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • S. Nakamura
    • 1
  • K. Abe
    • 1
  1. 1.Department of Legal MedicineTokyo Women's Medical CollegeTokyoJapan

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