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Human Genetics

, Volume 69, Issue 1, pp 28–31 | Cite as

Localization of the thyroglobulin gene by in situ hybridization to human chromosomes

  • Jean-Louis Bergé-Lefranc
  • Guy Cartouzou
  • Marie-Geneviève Mattéi
  • Edith Passage
  • Christiane Malezet-Desmoulins
  • Serge Lissitzky
Original Investigations

Summary

The human thyroglobulin gene was mapped by in situ hybridization whereby a 3H-labeled recombinant plasmid DNA containing a fragment of 2.3 kilobases of human thyroglobulin gene was hybridized to human chromosome preparations. A high proportion (25%) of hybridized metaphases exhibited silver grains at the distal portion of the long arm of chromosome 8. Analysis of the grain position at this site indicated that the chromosomal localization of the human thyroglobulin gene was 8q242-8q243.

Keywords

Internal Medicine Metabolic Disease Recombinant Plasmid Human Chromosome Chromosomal Localization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Jean-Louis Bergé-Lefranc
    • 1
    • 2
  • Guy Cartouzou
    • 1
    • 2
  • Marie-Geneviève Mattéi
    • 3
    • 4
  • Edith Passage
    • 3
    • 4
  • Christiane Malezet-Desmoulins
    • 1
    • 2
  • Serge Lissitzky
    • 1
    • 2
  1. 1.Laboratoire de Biochimie Médicale associé au CNRS (LA 178)Marseille Cédex 5France
  2. 2.Unité 38 de l'INSERMFaculté de MédecineMarseille Cédex 5France
  3. 3.Centre de Génétique MédicaleHôpital d'EnfantsMarseille Cédex 5France
  4. 4.Unité 242 de l'INSERMHôpital d'EnfantsMarseille Cédex 5France

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