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Human Genetics

, Volume 70, Issue 4, pp 337–340 | Cite as

Assignment of human pepsinogen A locus to the q12-pter region of chromosome 11

  • Bauke Zelle
  • A. Geurts van Kessel
  • J. de Wit
  • Pauline Evers
  • F. Arwert
  • J. C. Pronk
  • W. H. Mager
  • R. J. Planta
  • A. W. Eriksson
  • R. R. Frants
Original Investigations

Summary

A 0.9 kb cDNA fragment, corresponding to a large part of Rhesus monkey pepsinogen A mRNA, was used as probe for the chromosomal localization of the human pepsinogen A gene(s) using human-rodent somatic cell hybrids. Southern blot analysis of 14 human-Chinese hamster and three human-mouse cell hybrids, strongly indicates that the human PGA locus is on chromosome 11. The human-mouse hybrids, containing a translocation involving chromosome 11, allow sublocalization to the region q12-pter.

Keywords

Internal Medicine Blot Analysis Metabolic Disease Somatic Cell Southern Blot 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Bauke Zelle
    • 1
  • A. Geurts van Kessel
    • 2
  • J. de Wit
    • 2
  • Pauline Evers
    • 1
  • F. Arwert
    • 1
  • J. C. Pronk
    • 1
  • W. H. Mager
    • 3
  • R. J. Planta
    • 3
  • A. W. Eriksson
    • 1
  • R. R. Frants
    • 1
  1. 1.Institute of Human GeneticsFree UniversityAmsterdamThe Netherlands
  2. 2.Department of Cell Biology and GeneticsErasmus UniversityRotterdamThe Netherlands
  3. 3.Biochemical LaboratoryFree UniversityAmsterdamThe Netherlands

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