Acta Neuropathologica

, Volume 80, Issue 3, pp 287–294

Monocyte subpopulations in human gliomas: expression of Fc and complement receptors and correlation with tumor proliferation

  • T. Morimura
  • C. Neuchrist
  • K. Kitz
  • H. Budka
  • O. Scheiner
  • D. Kraft
  • H. Lassmann
Regular Papers

Summary

Cryostat sections of 12 gliomas and of 3 peritumoral brain tissue samples were investigated for mononuclear cell infiltration by immunohistochemistry, concentrating on cells expressing monocyte/macrophage markers. Only low numbers of T cells were detected in the tumors, whereas in average 20%–30% of all cells present in the samples were recognized by various macrophage markers. These cells carried surface epitopes with known function, like Fc-γ (Fcg) and complement receptors. Microglial cells, in comparison to typical debris laden macrophages, were only recognized by a restricted panel of macrophages markers (anti-Fcg receptors 1, 2, 3, complement receptor CR3, HLA DR, common leucocyte antigen CD45 and the monocyte marker RM3/1). In peritumoral tissue mainly dendritic, microglia-like cells were present, which revealed decreased expression of antigens CD4, RM3/1 and Fcg receptors in comparison to those in gliomas. A significant positive correlation was found between the number of RM3/1 or CR3 (CD11b)-positive cells and the proliferation rate of the tumors as documented by the number of bromodeoxyuridine-positive or Ki-67+ cells.

Key words

Glioma Macrophages Microglia Fc-receptors Complement receptors 

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • T. Morimura
    • 1
  • C. Neuchrist
    • 1
  • K. Kitz
    • 2
  • H. Budka
    • 1
  • O. Scheiner
    • 3
  • D. Kraft
    • 3
  • H. Lassmann
    • 1
    • 4
  1. 1.Neurologisches InstitutUniversität WienWienAustria
  2. 2.Neurochirurgische KlinikUniversität WienWienAustria
  3. 3.Institut für allgemeine und experimentelle PathologieUniversität WienWienAustria
  4. 4.Institut für HirnforschungÖsterreichische Akademie der WissenschaftenAustria
  5. 5.Department of NeurosurgeryHyogo College of MedicineNishinomiya, HyogoJapan

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