Acta Neuropathologica

, Volume 90, Issue 1, pp 51–56 | Cite as

White matter amyloid in Alzheimer's disease brain

  • Toshiki Uchihara
  • Hiromi Kondo
  • Haruhiko Akiyama
  • Kenji Ikeda
Regular Paper


Amyloid β-protein (Aβ) deposits in the white matter were investigated by the double immunohistochemical staining for Aβ and neuritic, glial or vascular components. Reactive astroglia and neurite abnormality were absent around Aβ deposits in the white matter (w-Aβ) even those with a core. The association of w-Aβ with blood vessels was not consistent. Aggregates of activated microglia were found to be the sole but a consistent accompaniment of Aβ deposits even in the absence of other components such as neuron, synapse, neurite abnormality and reactive astroglia, as observed in the white matter. This suggests that the aggregates of activated microglia most likely represent one of the factors promoting the process of Aβ deposition.

Key words

β-Protein White matter Laser scanning microscopy Microglia 


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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Toshiki Uchihara
    • 1
    • 2
    • 3
  • Hiromi Kondo
    • 2
  • Haruhiko Akiyama
    • 2
  • Kenji Ikeda
    • 2
  1. 1.Department of Neurology, Faculty of MedicineTokyo Medical and Dental UniversityTokyoJapan
  2. 2.Department of NeuropathologyTokyo Institute of PsychiatryTokyoJapan
  3. 3.Laboratories R. Escourolle, Service de NeuropathologieGroupe Hospitalier La Petié-La SalpêtrièreParis, CEDEXFrance

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