Rationale for local toxicity of calcium chelators
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Summary
Calcium chelating agents, such as ethylenediaminetetraacetate are toxic to urothelium. Their capacity to form complexes with calcium ions, which is the basis for their chemolytical effectiveness, also determines their toxicity. A decrease of chemolytical effectiveness by prior saturation of the chelator with Ca2+ or by lowering the pH to levels unfavourable for calcium binding significantly diminishes tissue injury. Exchange of Mg2+ ions does not, however, diminish tissue damage. The clinical use of calcium ligands is therefore unsafe.
Key words
Calcium oxalate Renal lithiasis Chemolysis EthylenediaminetetraacetatePreview
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References
- 1.Fisher RA (1950) Statistical methods for research workers, 11th edn. Oliver and Boyd, EdinburghGoogle Scholar
- 2.Gehres FR, Raymond S (1951) A new chemical approach to the dissolution of urinary calculi. J Urol 65:474Google Scholar
- 3.Kane MH, Rodman JS, Horten B, Reckler J, Marion D, Vaughan ED Jr (1989) Urothelial injury from ethylenediaminetetraacetic acid used as an irrigant in the urinary tract. J Urol 142:1359Google Scholar
- 4.Kuwahara M, Matsuo S, Kato T, Tsuchida S (1978) Effects of ethylenediaminetetraacetic 4-sodium solution on the surface of renal calculi and the urothelium. J Urol 120:11Google Scholar
- 5.Oosterlick W, Verbeeck R, Cuvelier C, Verplaetse H, Verbaeys A (1991) Toxicity of litholytic ethylenediaminetetraacetic acid and solutions to the urothelium of the rat and the dog. Urol Res 19:265Google Scholar
- 6.Oosterlinck M, Verbeeck R, Cuvelier C, Vergauwe D, Rappe B (1991) Toxicity to the urothelium of calcium chelating agents for chemolysis. J Urol (in press)Google Scholar
- 7.Suby HI (1952) Dissolution of urinary calculi. J Urol 68:96Google Scholar
- 8.Timmerman A, Kallistratos B (1966) Modern aspects of chemical dissolution of human renal calculi by irrigation. J Urol 95:469Google Scholar
- 9.Verplaetse A, Verbeeck RMH, Minnaert H, Oosterlick W (1985) The solubility of inorganic kidneystone components in the presence of acid-base sensitive complexing agents. Eur Urol 11:44Google Scholar
- 10.Verplaetse H, Verbeeck RMH, Verbaeys A, Oosterlinck W (1986) Solubility of calcium oxalate monohydrate and hydroxapatite in EDTA solution. J Urol 135:608Google Scholar
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© Springer-Verlag 1992