Acta Neuropathologica

, Volume 80, Issue 1, pp 92–94 | Cite as

Loss of neurons in the frontal cortex in AIDS brains

  • S. Ketzler
  • S. Weis
  • H. Haug
  • H. Budka
Short Original Communications

Summary

Neurons of Area 11 in the fronto-orbital cortex of 18 unselected AIDS brains are analyzed by means of stereology. Neurological abnormalities including dementing symptoms were described in eight patients. Neuropathology diagnosed human immunodeficiency virus (HIV)-specific changes in four, and diffuse poliodystrophy in eight brains. The majority (71.4%) of these brains was immunoreactive for HIV antigens when tested by immunocytochemistry. A significant loss of neurons is found as compared to normal controls. Neuronal density in AIDS brains is reduced by 18%, and the perikaryon volume fractions is reduced by 31%. Although only speculation on pathogenesis of this neuronal loss is possible at present, it may represent a part of the pathomorphological substrate of AIDS-related dementia. Moreover, it confirms by quantitative means damage to the cerebral cortex in AIDS which has been described only qualitatively as diffuse poliodystrophy.

Key words

Acquired immune deficiency syndrome (AIDS) Cerebral cortex Dementia Morphometry Neuronalloss 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Budka H (1989) Human immunodeficiency virus (HIV)-induced disease of the central nervous system: pathology and implications for pathogenesis. Acta Neuropathol 77:225–236Google Scholar
  2. 2.
    Budka H (1990) Human immunodeficiency virus envelope and core proteins in CNS tissues of patients with the acquired immune deficiency syndrome. Acta Neuropathol (in press)Google Scholar
  3. 3.
    Budka H (1990) Neuropathology of AIDS. Proc 14th World Congr Neurol. Int Congr Ser 883. Elsevier, Amsterdam (in press)Google Scholar
  4. 4.
    Budka H, Costanzi G, Cristina S, Lechi A, Parravicini C, Trabattoni R, Vago L (1987) Brain pathology induced by infection with the human immunodeficiency virus (HIV). A histological, immunocytochemical, and electron microscopical study of 100 autopsy cases. Acta Neuropathol (Berl) 75:185–198Google Scholar
  5. 5.
    Fischer PA, Enzenberger W (1987) Neurological complications in AIDS. J Neurol 234:269–279Google Scholar
  6. 6.
    Floderus S (1944) Untersuchungen über den Bau der menschlichen Hypophyse mit besondever Berücksichtigung der quantitativen mikromorphologischen Verhältisse. Acta Pathol Microbiol Scand 53 [Suppl]:80–98Google Scholar
  7. 7.
    Haug H (1967) Probleme und Methoden der Strukturzählung im Schnittpräparat. In: Weibel ER, Elias H (eds) Quantitative methods in morphology. Springer, Berlin, pp 58–78Google Scholar
  8. 8.
    Haug H, Kühl S, Mecke E, Sass NL, Wasner K (1984) The significance of morphometric procedures in the investigation of age changes in cytoarchitectonic structures of human brain. J Hirnforsch 25:353–374Google Scholar
  9. 9.
    Kleihues P, Lang W, Burger PC, Budka H, Vogt M, Maurer R, Lüthi R, Siegenthaler W (1985) Progressive diffuse leukoencephalopathy in patients with acquired immune deficiency syndrome (AIDS). Acta Neuropathol (Berl) 68:333–339Google Scholar
  10. 10.
    Levy JA, Shimabukuro J, Hollander H, Mills J, Kaminsky L (1985) Isolation of AIDS-associated retroviruses from cerebrospinal fluid and brain of patients with neurological symptoms. Lancet II:586–588Google Scholar
  11. 11.
    Navia BA, Jordan BD, Price RW (1986) The AIDS dementia complex. I. Clinical features. Ann Neurol 19:517–524Google Scholar
  12. 12.
    Navia BA, Cho ES, Petito CK, Price RW (1986) The AIDS dementia complex. II. Neuropathology. Ann Neurol 19:525–535Google Scholar
  13. 13.
    Price RW, Sidtis J, Rosenblum M (1988) The AIDS dementia complex: some current questions. Ann Neurol 23 [Suppl]:S27-S33Google Scholar
  14. 14.
    Price RW, Brew B, Sidtis J, Rosenblum M, Scheck AC, Cleavy P (1988) The brain in AIDS: central nervous, system HIV-1 infection and AIDS dementia complex. Science 239:586–592Google Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • S. Ketzler
    • 1
  • S. Weis
    • 1
  • H. Haug
    • 1
  • H. Budka
    • 2
  1. 1.Institut für AnatomieMedizinische Universität LübeckLübeckFederal Republic of Germany
  2. 2.Neurologisches InstitutUniversität WienWienAustria
  3. 3.Institut für PathologieMedizinische Universität LübeckLübeckFederal Republic of Germany

Personalised recommendations