Archives of Toxicology

, Volume 45, Issue 4, pp 325–329

Structure-activity relationships of some pyrethroids in rats

  • R. D. Verschoyle
  • W. N. Aldridge
Short Communication

DOI: 10.1007/BF00293813

Cite this article as:
Verschoyle, R.D. & Aldridge, W.N. Arch. Toxicol. (1980) 45: 325. doi:10.1007/BF00293813


The intravenous toxicity to the rat of 36 pyrethroids has been examined. With two exceptions they cause either (1) T-syndrome, consisting of aggressive sparring, sensitivity to external stimuli, fine progressing to gross whole body tremor and prostration or (2) CS-syndrome, consisting of pawing and burrowing behaviour, salivation, coarse tremor, progressing to sinuous writhing (choreoathetosis) and clonic seizures. The two exceptions presented a TS-syndrome with salivation associated with the T-syndrome. No clearcut relationship between chemical structure and symptoms of poisoning has emerged through some generalisations are discussed.

Key words

Pyrethroids Tremor Choreoathetosis 

Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • R. D. Verschoyle
    • 1
  • W. N. Aldridge
    • 2
  1. 1.MRC Toxicology UnitMedical Research Council LaboratoriesCarshaltonGreat Britain
  2. 2.Department of Pharmacology and ToxicologySchool of Medicine, University of Trondheim, Regional HospitalTrondheimNorway

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