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Human Genetics

, Volume 69, Issue 2, pp 157–160 | Cite as

The human gene encoding insulin-like growth factor I is located on chromosome 12

  • J. W. M. Höppener
  • P. de Pagter-Holthuizen
  • A. H. M. Geurts van Kessel
  • M. Jansen
  • S. D. Kittur
  • S. E. Antonarakis
  • C. J. M. Lips
  • J. S. Sussenbach
Original Investigations

Summary

A cDNA probe corresponding to mRNA encoding human somatomedin-C/insulin-like growth factor I (IGF-I) was used for the chromosomal assignment of the IGF-I gene. Southern-blot hybridization analysis of DNA from human-Chinese hamster somatic cell hybrids showed that the IGF-I gene is located on chromosome 12. Comparison of the chromosomal assignments of the IGF-I gene and two other members of the insulin gene family, with three c-ras oncogenes, reveals a remarkable association of the two gene families.

Keywords

Growth Factor Internal Medicine Gene Family Metabolic Disease Somatic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Brissenden JE, Ullrich A, Francke U (1984) Human chromosomal mapping of genes for insulin-like growth factors I and II and epidermal growth factor. Nature 310:781–784Google Scholar
  2. Tricoli JV, Rall LB, Scott J, Bell GI, Shows TB (1984) Localization of insulin-like growth factor genes to human chromosomes 11 and 12. Nature 310:784–786Google Scholar
  3. Van 't Veer LJ, Geurts van Kessel AHM, van Heerikhuizen H, van Ooyen A, Nusse R (1984) Molecular cloning and chromosomal assignment of the human homolog of int-1, a mouse gene implicated in mammary tumorigenesis. Molec Cell Biol 4:2532–2534Google Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • J. W. M. Höppener
    • 6
  • P. de Pagter-Holthuizen
    • 1
  • A. H. M. Geurts van Kessel
    • 2
  • M. Jansen
    • 3
  • S. D. Kittur
    • 4
  • S. E. Antonarakis
    • 4
  • C. J. M. Lips
    • 5
  • J. S. Sussenbach
    • 1
  1. 1.Laboratory for Physiological ChemistryState University of UtrechtThe Netherlands
  2. 2.Department of Cell Biology and GeneticsErasmus UniversityRotterdamThe Netherlands
  3. 3.Department of PediatricsState University of UtrechtUtrechtThe Netherlands
  4. 4.Department of PediatricsJohns Hopkins University, School of MedicineBaltimoreUSA
  5. 5.Department of Internal Medicine, State University HospitalState University of UtrechtUtrechtThe Netherlands
  6. 6.Institute of Molecular BiologyState University of UtrechtUtrechtThe Netherlands

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