Human Genetics

, Volume 73, Issue 1, pp 77–80

The genes for human gastrin and cholecystokinin are located on different chromosomes

  • T. Lund
  • A. H. M. Geurts van Kessel
  • S. Haun
  • J. E. Dixon
Original Investigations

Summary

The polypeptide hormones gastrin and cholecystokinin are structurally related, having the identical pentapeptide GWMDF located at their C-terminus. The precursors to these two hormones also show amino acid homology, suggesting that they may have a common ancestral origin. Recombinant DNA clones corresponding to gene fragments encoding human gastrin and cholecystokinin were used to determine their respective chromosomal localization by analyzing human-rodent cell lines. We have assigned the cholecystokinin gene to human chromosome 3q12-3pter and the gastrin gene to chromosome 17q.

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • T. Lund
    • 1
  • A. H. M. Geurts van Kessel
    • 2
  • S. Haun
    • 3
  • J. E. Dixon
    • 3
  1. 1.Iniversity Department of Clinical Chemistry 6321RigshospitaletCopenhagenDenmark
  2. 2.Department of Cell Biology and GeneticsErasmus UniversityRotterdamThe Netherlands
  3. 3.Department of BiochemistryPurdue UniversityWest LafayetteUSA

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