, Volume 30, Issue 6, pp 434–436 | Cite as

Rheological properties of white blood cells are changed in diabetic patients with microvascular complications

  • I. Vermes
  • E. T. Steinmetz
  • L. J. J. M. Zeyen
  • E. A. van der Veen
Rapid Communications


Erythrocyte and white blood cell suspensions were prepared from 22 Type 1 (insulin-dependent) and 37 Type 2 (non-insulin-dependent) diabetic patients and from 57 control subjects. Cell filterability was studied with the new “St. George's Filtrometer”, which can discriminate between cell deformability and filter occlusion. A pronounced increase of filter clogging was found in diabetic patients compared with control subjects. There was no significant difference between Type 1 and Type 2 diabetic patients, but a significantly increased clogging was found in patients with retinopathy compared with retinopathy-free patients. Considering that filter occlusion is mainly due to leucocytes, our results show a reduced filterability of white blood cells in diabetic patients. Altered white blood cell function may act as an additional factor in the impairment of microvascular circulation in diabetic patients.

Key words

Diabetes retinopathy haemorheology filterability erythrocyte leucocyte 


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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • I. Vermes
    • 1
  • E. T. Steinmetz
    • 2
  • L. J. J. M. Zeyen
    • 1
  • E. A. van der Veen
    • 3
  1. 1.Department of Clinical ChemistryH.d.K. HospitalOldenzaal
  2. 2.Department of OphthalmologyH.d.K. HospitalOldenzaal
  3. 3.Department of EndocrinologyFree University HospitalAmsterdamThe Netherlands

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