Diabetologia

, Volume 30, Issue 6, pp 380–385 | Cite as

The influence of physical training on glucose tolerance, insulin sensitivity, and lipid and lipoprotein concentrations in middle-aged hypertriglyceridaemic, carbohydrate intolerant men

  • R. M. Lampman
  • D. E. Schteingart
  • J. T. Santinga
  • P. J. Savage
  • C. R. Hydrick
  • D. R. Bassett
  • W. D. Block
Originals

Summary

The effects of 9 weeks of moderate intensity exercise training while on a weight-maintaining diet were studied in 19 untrained middle-aged, hypertriglyceridaemic, carbohydrate intolerant men. Initial mean maximum oxygen consumption was low (29.7±1.0 ml-min−1 · kg−1; mean±SEM) and improved (34.2±1.4ml·min−1·kg−1, p<0.01) with exercise training. Fasting glucose, insulin, lipid and lipoprotein concentrations did not change. While the abnormal glucose response to oral glucose did not change with training, insulin concentrations were significantly (p<0.05) lower at 90 and 120 min during the final oral glucose tolerance test. Insulin mediated glucose uptake did not change, indicating that the degree of exercise training failed to improve in vivo insulin sensitivity. Significant associations were found between the following parameters measured: fasting concentrations of triglycerides and insulin, very low density lipoprotein-triglycerides and glucose, and measures of in vivo insulin resistance and fasting insulin levels, suggesting that insulin resistance in these glucose intolerant subjects may play a role in their hypertriglyceridaemia. These data indicate that moderate increases in physical training alone are not sufficient to improve the carbohydrate, insulin and lipid metabolism of hypertriglyceridaemic, glucose intolerant men.

Key words

Insulin sensitivity hypertriglyceridaemia exercise training oxygen uptake serum lipids glycemic control 

References

  1. 1.
    Bjorntorp P, Fahlen M, Grimby G, Gustafson A, Holm J, Renstrom P, Schersten T (1972) Carbohydrate and lipid metabolism in middle-aged, physically well-trained men. Metabolism 21: 1037–1044Google Scholar
  2. 2.
    Ruderman NB, Ganda OP, Johansen K (1979) The effect of physical training on glucose tolerance and plasma lipids in maturity-onset diabetes. Diabetes 28 (1): 89–92Google Scholar
  3. 3.
    Reaven GM (1980) Insulin-independent diabetes mellitus: metabolic characteristics. Metabolism 29: 445–454Google Scholar
  4. 4.
    Olefsky JM, Farquhar JW, Reaven GM (1974) Reappraisal of the role of insulin in hypertriglyceridaemia. Am J Med 57: 551–560Google Scholar
  5. 5.
    Castelli WP, Doyle JT, Gordon T, Hames CG, Hjortland MC, Hulley SB, Kagen A, Zukel WJ (1977) HDL cholesterol and other lipids in coronary heart disease: The Cooperative Lipoprotein Phenotyping Study. Circulation 55: 767–772Google Scholar
  6. 6.
    Lampman RM, Santinga JT, Savage PJ, Bassett DR, Hydrick CR, Flora JD Jr, Block WD (1985) Effect of exercise training on glucose tolerance, in vivo insulin sensitivity, lipid and lipoprotein concentrations in middle-aged men with mild hypertriglyceridaemia. Metabolism 34: 205–211Google Scholar
  7. 7.
    World Health Organization Expert Committee (1980) Second report on diabetes mellitus. Technical Report Series No 646, Geneva, SwitzerlandGoogle Scholar
  8. 8.
    Keys A, Fidanza F, Karvonen MJ, Kimura N, Taylor HL (1972) Indices of relative weight and obesity. J Chron Dis 25: 329–343Google Scholar
  9. 9.
    Bondar RJL, Mean D (1974) Evaluation of glucose-6-phosphate dehydrogenase from leuconostocmesenteroids in the hexokinase method for determining glucose in serum. Clin Chem 20: 586–590Google Scholar
  10. 10.
    Morgan CR, Lazarow A (1963) Immunoassay of insulin: two antibody systems. Diabetes 12: 115–126Google Scholar
  11. 11.
    Lipid research clinics manual of laboratory operations, Vol 1 (1974) Lipid and lipoprotein analysis. HEW No. NIH 75-628. Washington, DC, US Government Printing OfficeGoogle Scholar
  12. 12.
    Nichols AB, Ravenscroft C, Lamphier DE, Ostrander LD Jr (1976) Daily nutritional intake and serum lipid levels. The Tecumseh Study. Am J Clin Nutr 29: 1384–1392Google Scholar
  13. 13.
    Shen SW, Reaven GM, Farquhar JW (1970) Comparison of impedance to insulin-mediated glucose uptake in normal subjects and in subjects with latent diabetes. J Clin Invest 49: 2151–2160Google Scholar
  14. 14.
    DeFronzo RA, Tobin JD, Andres R (1979) Glucose clamp technique: A method for quantifying insulin secretion and resistance. Am J Physiol 237: E214–223Google Scholar
  15. 15.
    Winer BJ (1971) Statistical principles in experimental design, 2nd edn. McGraw-Hill, New YorkGoogle Scholar
  16. 16.
    Schneider SH, Amorosa LF, Khachadurian AK, Ruderman NB (1984) Studies on the mechanism of improved glucose control during regular exercise in type 2 (non-insulin-dependent) diabetes. Diabetologia 26: 355–360Google Scholar
  17. 17.
    Trovati M, Carta Q, Cavalot F, Vitali Sm Banaudi C, Lucchina PG, Fiocchi F, Emanuelli G, Lenti G (1984) Influence of physical training on blood glucose control, glucose tolerance, insulin secretion, and insulin action in non-insulin-dependent diabetic patients. Diabetes Care 7: 416–420Google Scholar
  18. 18.
    Bogardus C, Ravussin E, Robbins DC, Wolfe RR, Horton ES, Sims EAH (1984) Effects of physical training and diet therapy on carbohydrate metabolism in patients with glucose intolerance and non-insulin-dependent diabetes mellitus. Diabetes 33: 311–318Google Scholar
  19. 19.
    Nagulesparan M, Savage PJ, Unger RH, Bennett PH (1979) A simplified method using somatostatin for the assessment of in vivo insulin resistance over a range of obesity. Diabetes 28: 980–983Google Scholar
  20. 20.
    Reitman JS, Vasquez B, Klimes I, Nagulesparan M (1984) Improvement of glucose homeostasis after exercise training in noninsulin-dependent diabetes. Diabetes Care 7: 434–441Google Scholar
  21. 21.
    Reaven GM, Mejean L, Villaume C, Drouin P, Debry G (1983) Plasma glucose and insulin response to oral glucose in nonobese subjects and patients with endogenous hypertriglyceridaemia. Metabolism 32: 447–450Google Scholar
  22. 22.
    Ruderman NB, Schneider SH, Berchtold P (1981) The “metabolically obese”, normal weight individual. Am J Clin Nutr 34: 1617–1621Google Scholar
  23. 23.
    Enger SC, Ritland S (1973) Glucose tolerance, insulin release and lipoprotein pattern in patients after myocardial infarction. Acta Med Scand 194: 97–101Google Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • R. M. Lampman
    • 1
  • D. E. Schteingart
    • 1
  • J. T. Santinga
    • 1
  • P. J. Savage
    • 1
  • C. R. Hydrick
    • 1
  • D. R. Bassett
    • 1
  • W. D. Block
    • 1
  1. 1.Divisions of Cardiology, Endocrinology, and Hypertension, Department of Internal Medicine and the Clinical Research CenterUniversity of Michigan Medical School, Division of CardiologyAnn ArborUSA

Personalised recommendations