Human Genetics

, Volume 72, Issue 3, pp 262–265 | Cite as

Assignment of the human homologue of Pim-1, a mouse gene implicated in leukemogenesis, to the pter-q12 region of chromosome 6

  • H. T. Cuypers
  • G. Selten
  • A. Berns
  • A. H. M. Geurts van Kessel
Original Investigations

Summary

Viral leukemogenesis in mice is frequently initiated by proviral activation of a highly conserved cellular gene called Pim-1. Here we report the chromosomal localization of the human homologue by Southern blot analyses of DNAs obtained from human-rodent somatic cell hybrids. The single copy human homologue was assigned to the 6pter-q12 segment.

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • H. T. Cuypers
    • 1
  • G. Selten
    • 1
  • A. Berns
    • 1
  • A. H. M. Geurts van Kessel
    • 2
  1. 1.Department of BiochemistryUniversity of NijmegenNijmegenThe Netherlands
  2. 2.Department of Cell Biology and GeneticsErasmus UniversityRotterdamThe Netherlands

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