Human Genetics

, Volume 78, Issue 4, pp 299–312 | Cite as

DNA polymorphism and the study of disease associations

  • David N. Cooper
  • John F. Clayton
Review
Received:
Accepted:

Summary

Recombinant DNA approaches to disease analysis may be as applicable to studies of disease association as they are to the analysis and diagnosis of single-gene defects. Population and/or family association analyses, using restriction fragment length polymorphisms around candidate genes as markers, have been employed to study conditions such as atherosclerosis and disease with an HLA-association. Progress made to date in disease-association studies using recombinant DNA methodology is reviewed, the rationale behind such studies is examined and associated problems and pitfalls discussed.

Keywords

Atherosclerosis Internal Medicine Candidate Gene Metabolic Disease Fragment Length 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • David N. Cooper
    • 1
  • John F. Clayton
    • 2
  1. 1.Haematology DepartmentKing's College Hospital School of Medicine and DentistryLondonUK
  2. 2.MRC Clinical and Population Cytogenetics UnitWestern General HospitalEdinburghUK

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