Human Genetics

, Volume 32, Issue 2, pp 211–215 | Cite as

Pathomorphological changes in an early spontaneous abortus with triploidy (69,XXX)

  • V. P. Kulazenko
  • L. G. Kulazenko
Clinical Case Reports


Triploid (69,XXX) spontaneous abortus with a gestational age of 14–15 weeks (anatomical age of the embryo was 6 weeks) was analyzed macro- and microscopically. There were hydatidiform swelling and cystic degeneration of the villi, without proliferation of the trophoblast of cells, aplasia of one umbilical artery. The embryo had the following anomalies: cranial and caudal hypoplasia; aplasia of the facial structures (aprosopia), ocular vesicles, nasal stalk, extremity buds, somites, upper jaw, hyoid and pharyngeal arches, esophagus; trachea, Rathke's pouch and oropharyngeal cavity; encephalocele, focal anomalous rudiments of cartilage in the chordamesoderm, atresia of the stomodeal foramen and persistance of the lenticular placode.


Internal Medicine Metabolic Disease Umbilical Artery Facial Structure Cystic Degeneration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Edwards, J. H., Guncken, C., Rushton, R.: Three cases of triploidy in man. Cytogenetics 6, 81–104 (1967)Google Scholar
  2. Geisler, M., Kleinebrecht, I.: Histologische Analysen von triploiden Spontanaborten. Humangenetik 16, 283–294 (1972)Google Scholar
  3. Knorre, A. G.: The brief sketch of the embryology human. Leningrad (USSR) 1967Google Scholar
  4. Kvitniski-Rijov: Changes in the neural rudiments of the early pathological of embryos human. Arch. Pat. 3, 58–62 (1951)Google Scholar
  5. Levy, I., Chadeyron, P.: Avortements spontanes et triploidie. Rev. franç. Gynéc. 67, 327–342 (1972)Google Scholar
  6. Mikamo, K.: Anatomic and chromosomal anomalies in spontaneous abortions. Amer. J. Obstet. Gynec. 106, 243–254 (1970)Google Scholar
  7. Nayak, S. K.: Pathology of abortion: essential abortion. Obstet. and Gynec. 32, 316–324 (1968)Google Scholar
  8. Nujoks, H.: Culture of tissues from spontaneous human abortions (preliminary work for chromosome analysis). Acta cytol. (Philad.) 7, 300–304 (1963)Google Scholar
  9. Paterson, W., Hobson, S., Smaet, G., Bain, A.: Two cases of hydatidiform degeneration of the placenta with fetal abnormality and triploid chromosome constitution. J. Obstet. Gynaec. Brit. Cwlth 78, 136–142 (1971)Google Scholar
  10. Patten, B.: Embryology of the human. New York: Blakiston Company 1959Google Scholar
  11. Walker, S., Andrews, J.: Three further cases of triploidy in man surviving to birth. J. med. Genet. 10, 135–141 (1973)Google Scholar
  12. Willis, R. A.: The borderland of embryology and pathology. London: Butterworths 1962Google Scholar

Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • V. P. Kulazenko
    • 1
  • L. G. Kulazenko
    • 1
  1. 1.Medical Genetics Laboratory and Department of PathologyMedical InstituteMinskUSSR

Personalised recommendations