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Humangenetik

, Volume 3, Issue 2, pp 121–126 | Cite as

Human red cell acid phosphatase polymorphism

A study on gene frequency and forensic use of the system in cases of disputed paternity
  • Walter Fuhrmann
  • Karl-Henning Lichte
Article

Abstract

Red cell acid phosphatase phenotypes were determined in 401 unrelated persons from Southwestern Germany. The frequencies of genes Pa, Pb and Pc were estimated to be p=0.328, q=0.630 and r=0.042.

Experiences in 101 cases of disputed paternity with 151 men involved are reported. 22 men could be excluded from paternity on the basis of red cell acid phosphatase phenotypes.

In all 140 mother-child-combinations tested the distribution of red cell acid phosphatase variants was compatible with the genetic model suggested by Hopkinson et al.

Usefulness of the system in forensic cases of disputed paternity is discussed.

Keywords

Internal Medicine Metabolic Disease Acid Phosphatase Genetic Model Forensic Case 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Literature

  1. Hopkinson, D. A., H. Harris, and N. Spencer: Red cell acid phosphatase variants: a new human polymorphism. Nature (Lond.) 199, 969 (1963).Google Scholar
  2. —: Genetical studies on human red cell acid phosphatase. American J. hum. Genet. 16, 141 (1964).Google Scholar
  3. Harris, H.: Personal communication; cit. by L. Lai et al.Google Scholar
  4. Lai, L., S. Nevo, and A. G. Steinberg: Acid phosphatase of human red cells: Predicted phenotype conforms to a genetic hypothesis. Science 145, 1187 (1964).Google Scholar
  5. Prokop, O.: Neue Ergebnisse auf dem Gebiet der Blut- und Serumgruppen. Vortrag Tgg. Dtsch. Gesellsch. f. Gerichtl. und Soz. Med., Freiburg/Br. 7. 10. 1966; Personal communication.Google Scholar
  6. Radam, G., u. H. Strauch: Populationsgenetik der sauren Erythrocytenphosphatase. Humangenetik 2, 378 (1966).Google Scholar

Copyright information

© Springer-Verlag 1966

Authors and Affiliations

  • Walter Fuhrmann
    • 1
  • Karl-Henning Lichte
    • 1
  1. 1.Institut für Anthropologie und Humangenetik der Universität HeidelbergHeildellbergGermany

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