Human Genetics

, Volume 72, Issue 4, pp 352–353

The gene encoding for the major brain proteolipid (PLP) maps on the q-22 band of the human X chromosome

  • M. G. Mattei
  • P. M. Alliel
  • A. Dautigny
  • E. Passage
  • D. Pham-Dinh
  • J. F. Mattei
  • P. Jollès
Short Communications

Summary

Recombinant plasmid clone p23 containing the cDNA proteolipid (PLP) sequence was localized by in situ hybridization on band q22 of the human X chromosome. This localization may have implications for X-linked demyelination diseases such as Pelizacus-Merzbacher disease in man.

References

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • M. G. Mattei
    • 1
  • P. M. Alliel
    • 2
  • A. Dautigny
    • 2
  • E. Passage
    • 1
  • D. Pham-Dinh
    • 2
  • J. F. Mattei
    • 1
  • P. Jollès
    • 2
  1. 1.U-242 INSERM Centre de Génétique MédicaleHôpital d'Enfants de la TimoneMarseille Cedex 5France
  2. 2.Laboratoire des Protéines (Unité CNRS 1188 alliée à l'INSERM)Université de Paris VParis Cedex 06France

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