Mammalian Genome

, Volume 4, Issue 2, pp 78–82 | Cite as

Mapping of the human homologs of the murine paired-box-containing genes

  • Alison J. Pilz
  • Susan Povey
  • Peter Gruss
  • Catherine M. Abbott
Original Contributions


Mutations in paired-box-containing (Pax) genes have recently been found to be the primary lesions underlying human genetic disorders such as Waardenburg's Syndrome type 1 and mouse developmental mutants such as undulated (un), splotch (Sp), and small eye (Sey). In addition, PAX-6 is a strong candidate gene for aniridia in man. Eight independent Pax genes have been isolated in the mouse. All eight map to distinct regions of the mouse genome; they do not appear to be clustered in the same way as some groups of homeobox-containing genes. We have now mapped the human homologs of all eight of these genes; PAX genes are found on human Chromosomes (Chr) 1, 2, 7, 9, 10, 11, and 20.


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Copyright information

© Springer-Verlag New York Inc 1993

Authors and Affiliations

  • Alison J. Pilz
    • 1
  • Susan Povey
    • 2
  • Peter Gruss
    • 3
  • Catherine M. Abbott
    • 1
  1. 1.Department of Genetics and BiometryUniversity College LondonLondonUK
  2. 2.MRC Human Biochemical Genetics UnitUniversity College LondonLondonUK
  3. 3.Department of BiologyMax Planck Institute of Biophysical ChemistryGöttingenFRG

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