Archives of Microbiology

, Volume 160, Issue 2, pp 158–161 | Cite as

Type selective inhibition of microbial fatty acid synthases by thiolactomycin

  • Nariaki Arimura
  • Toshi Kaneda
Short Communications


The antibiotic, thiolactomycin, is known to selectively inhibit the Type II straight-chain fatty acid synthase (monofunctional enzyme system, e.g. Escherichia coli enzyme) but not Type I straight-chain fatty acid synthase (multifunctional enzyme system, e.g. Saccharomyces cerevisiae enzyme). We have studied the effect of thiolactomycin on the branched-chain fatty acid synthases from Bacillus subtilis, Bacillus cereus, and Bacillus insolitus. Fatty acid synthase from all three Bacilli was not inhibited or only slightly inhibited by thiolactomycin. E. coli synthase, as expected, was strongly inhibited by thiolactomycin. Branched-chain fatty acid synthase from Bacillus species is a monofunctional enzyme system but, unlike Type II E. coli synthase, it is largely insensitive to thiolactomycin.

Key words

Branched-chain fatty acids Fatty acid synthase Thiolactomycin Selective inhibitor Bacillus subtilis Bacillus cereus Bacillus insolitus Escherichia coli 


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Copyright information

© Springer Verlag 1993

Authors and Affiliations

  • Nariaki Arimura
    • 1
  • Toshi Kaneda
    • 1
  1. 1.Alberta Research CouncilEdmontonCanada

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