Human Genetics

, Volume 82, Issue 1, pp 49–54 | Cite as

The absence of type II collagen and changes in proteoglycan structure of hyaline cartilage in a case of Langer-Saldino achondrogenesis

  • S. P. Feshchenko
  • I. A. Rebrin
  • V. P. Sokolnik
  • B. M. Sher
  • B. P. Sokolov
  • V. N. Kalinin
  • G. I. Lazjuk
Original Investigations


Structural analysis of hyaline cartilage extracellular matrix components from the ribs and knee joint of a stillborn female with type II achondrogenesis was carried out. The absence of type II collagen, a decrease in the amount of proteoglycans (PG), and structural changes in PG, namely, increased electrophoretic mobility of PG, lower relative content of chondroitin 4-sulfate (Ch4-S), lower molecular weight and decreased total chondroitin sulfate (ChS) sulfation, were detected. Increased amounts of type I and type III collagens, atypical for hyaline cartilage, were revealed. Among the link proteins (LPs), a large protein with a mol. wt. of 48 kDa was predominant. Molecular and cellular mechanisms of the pathogenesis of achondrogenesis (“chondrogenesis imperfecta”) are discussed. The data obtained suggest that the primary defect in type II achondrogenesis involves ChS or type II collagen synthesis.


Collagen Lower Molecular Weight Knee Joint Electrophoretic Mobility Relative Content 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • S. P. Feshchenko
    • 1
  • I. A. Rebrin
    • 2
  • V. P. Sokolnik
    • 1
  • B. M. Sher
    • 2
  • B. P. Sokolov
    • 2
  • V. N. Kalinin
    • 2
  • G. I. Lazjuk
    • 1
  1. 1.Byelorussian Institute for Hereditary DiseasesMinskUSSR
  2. 2.Institute of Medical Genetics of the USSR Academy of Medical SciencesMoscowUSSR

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