Human Genetics

, Volume 83, Issue 3, pp 295–296 | Cite as

Expression of the human ETS-2 oncogene in normal fetal tissues and in the brain of a fetus with trisomy 21

  • M. Baffico
  • L. Perroni
  • A. Rasore-Quartino
  • P. Scartezzini
Short Communications
Received:
Revised:

Summary

The expression of the ETS-2 proto-oncogene, located on chromosome 21, in normal fetal tissues and in neural tissue of a fetus affected by Down syndrome has been investigated. The results show that the ETS-2 proto-oncogene is expressed in almost all the tissues examined and that it is transcribed at constant levels in neural tissue between the 13th and 24th weeks. ETS-2 experession appeared to be slightly increased in Down syndrome brain compared with that of normal controls of the same gestational age.

Keywords

Internal Medicine Normal Control Metabolic Disease Down Syndrome Constant Level 
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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • M. Baffico
    • 1
    • 3
  • L. Perroni
    • 2
  • A. Rasore-Quartino
    • 1
  • P. Scartezzini
    • 1
  1. 1.Divisione di PediatriaGenovaItaly
  2. 2.Centro Regionale di Genetica Umana Ospedale GallieraGenovaItaly
  3. 3.Centro Studi Regionale Sindrome di DownGenovaItaly

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