Human Genetics

, Volume 83, Issue 3, pp 264–266 | Cite as

Sublocalization of von Willebrand factor pseudogene to 22q11.22–q11.23 by in situ hybridization in a 46,X,t(X;22)(pter;q11.21) translocation

  • P. Patracchini
  • E. Calzolari
  • V. Aiello
  • P. Palazzi
  • P. Banin
  • G. Marchetti
  • F. Bernardi
Original Investigations

Summary

The von Willebrand factor pseudogene, previously mapped to chromosome 22, was sublocalized by in situ hybridization using as probe a von Willebrand factor cDNA fragment completely contained in the pseudogenic region. Chromosome spreads were from a patient carrying a unique balanced de novo translocation 46,X,t(X;22)(pter;q11.21). Silver grain analysis indicated that the human von Willebrand factor pseudogene is located on 22q11.22–q11.23, a region relevant for several somatic and constitutional chromosomal alterations.

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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • P. Patracchini
    • 1
  • E. Calzolari
    • 2
  • V. Aiello
    • 2
  • P. Palazzi
    • 2
  • P. Banin
    • 3
  • G. Marchetti
    • 1
  • F. Bernardi
    • 1
  1. 1.Centro di Studi Biochimici delle Patologie del Genoma UmanoUniversità di FerraraFerraraItaly
  2. 2.Istituto di Genetica MedicaUniversità di FerraraFerraraItaly
  3. 3.Divisione Pediatrica ArcispedaleS. Anna USL 31FerraraItaly

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