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Human Genetics

, Volume 76, Issue 2, pp 196–198 | Cite as

α-Thalassemia in Saudi Arabia: deletion pattern

  • M. A. F. El-Hazmi
Original Investigations

Summary

α-Thalassemia exists at a high prevalence in several regions of Saudi Arabia. The restriction endonucleases Bam HI and BglII were used to investigate the molecular basis of deletion type of α-thalassemia in 226 subjects from the eastern and 61 subjects from the northwestern regions of the country. The arrangements-α/αα and-α/-α were common. BglII digestion revealed the existence of rightward deletion in a majority of the cases. Leftward deletions, both homozygous and heterozygous, were also identified. Triple α-gene arrangements -α/αα and -α/-α were observed at a low frequency in both regions.

Keywords

Internal Medicine Restriction Endonuclease Metabolic Disease Molecular Basis Northwestern Region 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • M. A. F. El-Hazmi
    • 1
    • 2
  1. 1.Department of Medical BiochemistryCollege of MedicineRiyadhSaudi Arabia
  2. 2.King Khalid HospitalRiyadhSaudi Arabia

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