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Human Genetics

, Volume 77, Issue 3, pp 205–209 | Cite as

The Kidd (JK) blood group locus assigned to chromosome 18 by close linkage to a DNA-RFLP

  • G. A. Geitvik
  • B. Høyheim
  • T. Gedde-Dahl
  • K. H. Grzeschik
  • R. Lothe
  • H. Tomter
  • B. Olaisen
Original Investigations

Summary

The close linkage between the PstI-restriction fragment length polymorphism (RFLP) disclosed by the L2.7 genomic DNA probe and the Kidd blood group locus is described. The maximum lod score is+8.53 at recombination fraction \(\hat \theta = 0.03\). The upper probability limit of the recombination fraction is θ =1 0.11. The L2.7 probe, previously assigned provisionally to chromosome 17, is by the present study assigned to chromosome 18. This also assigns the Kidd blood group locus (JK) to chromosome 18. Accepting previous deletion mapping, the shortest regions of overlap (SRO) for JK is 18q11-12, whereas one of our hybrids assigns L2.7 to 18q11-pter, suggesting centromeric localisation of the linkage group. JK has been assigned previously to chromosome 2 because of its provisional linkage to IGK which in turn has been mapped to 2p12. Our own JK-IGK linkage data do in fact support the previous positive lod scores at high recombination fractions (total lods+4.12 at θ1 = 0.30). No obvious explanation for the conflicting gene mapping data is found.

Keywords

Linkage Group Fragment Length Polymorphism Linkage Data Close Linkage Probability Limit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • G. A. Geitvik
    • 1
  • B. Høyheim
    • 1
  • T. Gedde-Dahl
    • 1
  • K. H. Grzeschik
    • 2
  • R. Lothe
    • 1
  • H. Tomter
    • 1
  • B. Olaisen
    • 3
  1. 1.Department of Genetics, Institute for Cancer ResearchThe Norwegian RadiumhospitalOslo 3Norway
  2. 2.Institut für Humangenetik der UniversitätMünsterGermany
  3. 3.Department of Forensic MedicineUniversity of OsloOslo 1Norway

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