Human Genetics

, Volume 75, Issue 4, pp 345–349

Fragile sites, chromosome evolution, and human neoplasia

  • Rosa Miró
  • Inmaculada Concepción Clemente
  • Carmen Fuster
  • José Egozcue
Original Investigations

Summary

In a study of the possible relationship between human fragile sites, chromosomal rearrangements related to neoplasia, and chromosome regions involved in evolutionary changes, we have found that 17 fragile sites related to cancer, 15 fragile sites not related to cancer, and 17 non-fragile regions also related to human malignancy correspond or are close to bands involved in rearrangements that have taken place during chromosomal evolution in primates.

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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • Rosa Miró
    • 1
    • 2
  • Inmaculada Concepción Clemente
    • 1
  • Carmen Fuster
    • 1
  • José Egozcue
    • 1
    • 2
  1. 1.Departament de Biologia Cel.lular i FisiologiaUniversitat Autònoma de BarcelonaBellaterra (Barcelona)Spain
  2. 2.Institut de Biologia Fonamental “Vincent Villar Palasí”Universitat Autònoma de BarcelonaBallaterra (Barcelona)Spain

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