Human Genetics

, Volume 81, Issue 4, pp 385–387 | Cite as

Regional localization and molecular characterization of a DNA sequence on the long arm of chromosome 22

  • Elisabeth Göttert
  • Reinhold Metzdorf
  • Uwe Färber
  • Nikolaus Blin
Short Communications
Received:
Revised:

Summary

A human genomic DNA fragment, p22hom13 (D22S16), was isolated from a chromosome 22-specific library. After elimination of repetitive sequences, a single copy BamHI-EcoRI fragment was subcloned into pTZ18. By using mouse/human somatic cell hybrids and in situ hybridization, the new DNA probe was mapped to chromosome 22q13-qter. Its application in the analysis of the distal part of chromosome 22 and its diagnostic use in translocations are discussed.

Keywords

Internal Medicine Metabolic Disease Somatic Cell Regional Localization Molecular Characterization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • Elisabeth Göttert
    • 1
  • Reinhold Metzdorf
    • 1
  • Uwe Färber
    • 1
  • Nikolaus Blin
    • 1
  1. 1.Institut für HumangenetikUniversitätsklinikHomburg/SaarFederal Republic of Germany

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