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Human Genetics

, Volume 42, Issue 2, pp 157–162 | Cite as

Mitotic cycles in human cell strains with sex chromosomes aneuploidy

  • V. I. Kukharenko
  • K. N. Grinberg
  • A. M. Kuliev
Original Investigations

Summary

A persistence of the embryonic type of mitotic cycle was found in postnatal strains with aneuploidy of sex chromosomes (45,X; 47,XXX; 49,XXXXX;47,XYY;49,XXXXY). Life-span and proliferating activity of the strains did not differ from those of diploid postnatal cells.

Keywords

Internal Medicine Metabolic Disease Human Cell Proliferate Activity Cell Strain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Alvesalo, L., Osborn, B. H., Kari, M.: The 47,XYY male, Y chromosome and tooth size. Amer. J. Hum. Genet. 27, 53–61 (1975)Google Scholar
  2. Barlow, P. W.: Differential cell division in human X chromosome mosaics. Humangenetik 14, 122–127 (1972)Google Scholar
  3. Barlow, P.: The influence of inactive chromosomes on human development. Anomalous sex chromosome complements and the phenotype. Humangenetik 17, 105–136 (1973)Google Scholar
  4. Brautbar, C., Payne, R., Hayflick, L.: Fate of HL-A antigens in agin cultured human diploid cell strains. Exp. Cell Res. 75, 31–38 (1972)Google Scholar
  5. Cristofalo, V. J., Sharf, B. B.: Cellular senescence and DNA synthesis: Thymidine incorporation as a measure of population age in human diploid cells. Exp. Cell Res. 76, 419–427 (1973)Google Scholar
  6. Goldstein, S., Littlefield, J. W., Soeldner, J. S.: Diabetes mellitus and aging: Diminished plating efficiency of cultured human fibroblasts. Proc. Natl. Acad. Sci. USA 64, 155–160 (1969)Google Scholar
  7. Hayflick, L.: The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37, 614–636 (1965)Google Scholar
  8. Kukharenko, V. I., Kuliev, A. M., Grinberg, K. N., Terskikh, V. V.: Cell cycles in human diploid and aneuploid strains. Humangenetik 24, 285–296 (1974)Google Scholar
  9. Kukharenko, V. I., Grinberg, K. N., Kuliev, A. M.: Mitotic cycles in human diploid fibroblast-like cell strains (in Russian). Cytology (Leningrad) 19, 940–942 (1977)Google Scholar
  10. Martin, G., Spraque, C., Epstein, C.: Replicative life-span of cultivated human cells. Lab. Invest. 23, 86–92 (1970)Google Scholar
  11. Paton, G. R., Silver, M. F., Allison, A. C.: Comparison of cell cycle time in normal and trisomic cells. Humangenetik 23, 173–182 (1974)Google Scholar
  12. Quastler, H., Sherman, T. G.: Cell population kinetics in the intestinal epithelium of the mouse. Exp. Cell Res. 17, 420–429 (1959)Google Scholar

Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • V. I. Kukharenko
    • 1
  • K. N. Grinberg
    • 1
  • A. M. Kuliev
    • 1
  1. 1.Institute of Medical Genetics AMSMoscowUSSR

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