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Water, Air, and Soil Pollution

, Volume 57, Issue 1, pp 555–567 | Cite as

Metallothioneins and detoxification. Is the use of detoxication protein for mts a language abuse?

  • Richard P. Cosson
  • Claude Amiard-Triquet
  • Jean-Claude Amiard
Part III Physiological and Toxicological Aspects of Metals

Abstract

Our own results and a literature review led us to reconsider the detoxifying function of MTs in living organisms. Despite the fact that many authors have observed a synthesis or a level increase of MTs as a response to toxic metal uptake, arguments exist which tend us to give to MTs a strict zinc homeostasic function. Many experiments have been conducted using non-natural routes of exposure and/or concentrations far from those observed even in heavily polluted environments. Zinc is the only metal for which a primary induction has been established. Correlations between zinc and MTs levels are frequently observed, specially at the early stages of life. Our knowledge about metallic cluster structure and our experimental results about inter-metallic competition for binding-sites on the apoprotein, support the idea of substitution processes instead of de novo synthesis in most cases of contamination, leading frequently to acclimation.

Keywords

Zinc Polluted Environment Living Organism Toxic Metal Level Increase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Andersen, R.A., and Wen, X.L.: 1986, Comp. Biochem. Physiol. 84C, 345.Google Scholar
  2. Blazka, M.E., Nolan, C.V., and Shaikh, Z.A.: 1988, J. Appl. Toxicol. 8(3), 217.Google Scholar
  3. Bonham, K., and Gedamu, L.: 1984 Biosci. Reports 4, 633.Google Scholar
  4. Bracken, W.M., and Klaassen, C.D.: 1987 J. Toxicol. Environ. Hlth 22, 163.Google Scholar
  5. Bradley, R.W., Du Quesnay, C., and Sprague, J.B.: 1985 J. Fish. Biol. 27, 367.Google Scholar
  6. Bremner, I., Davies, N.T., and Mills, C.F.: 1973 Biochem. Soc. Trans. 1, 982.Google Scholar
  7. Brown, D.A., Brawden, C.A., Chatel, K.W., and Parsons, T.R.: 1977 Environ. Conserv. 4, 213.Google Scholar
  8. Brown, D.A., and Parsons, T.R.: 1978 J. Fish. Res. Bd. Can. 35, 880.Google Scholar
  9. Brown, M.W., Thomas, D.G., Shurben, D., Solbe, J.F. De L.G. Kay, J., and Cryer, A.: 1986 Comp. Biochem. Physiol. 84C(2),213.Google Scholar
  10. Cherian, M.G., and Nordberg, M.: 1983 Toxicology 28, 1.Google Scholar
  11. Cosson, R.P. : 1987 Thèse de Doctorat d'Etat es Sciences Naturelles, Université de Paris XI.Google Scholar
  12. Cosson, R.P., Amiard, J-Cl., and Amiard-Triquet, C.: 1988 Ecotox. Environ. Saf. 15, 107.Google Scholar
  13. Cosson, R.P.: 1990 Comp. Biochem. Physiol. 94C(1), 243.Google Scholar
  14. Cousins, R.J.: 1979 in Metallothionein. Kagi and Nordberg (eds) Boston: Birkhauser Verlag, 293.Google Scholar
  15. Day, F.A., Funk, A.E., and Brady, F.O.: 1984 Chem. Biol. Interact. 50, 159.Google Scholar
  16. Duncan, D.A., and Klaverkamp, J.F.: 1983 Can. J. Fish. Aquat. Sci. 40, 128.Google Scholar
  17. Feldman, S.L., Failla, M.L., and Cousins, R.J.: 1978 Biochem. Biophys. Acta. 544, 638.Google Scholar
  18. Forstner, U., and Wittmann, G.T.W.: 1981 Metal Pollution in the Aquatic Environment, Springer-Verlag, Berlin.Google Scholar
  19. Foulkes, E.C. (ed.): 1982 Biological Roles of Metallothioneins, Elsevier : North-Holland, New-York.Google Scholar
  20. Funk, A.E., Day, F.A., and Brady, F.O.: 1987 Comp. Biochem. Physiol. 86C(1), 1.Google Scholar
  21. Georing, P.L., and Klaassen, C.D.: 1984 J. Toxicol. Environ. Hlth. 14, 803.Google Scholar
  22. Gregus, Z., and Klaassen, C.D.: 1986 Toxicol. Appl. Pharmacol. 85, 24.Google Scholar
  23. Hamilton, S.J., Mehrle, P.M., and Jones, J.R.: 1987 Trans. Am. Fish, Soc. 116, 551.Google Scholar
  24. Harrison, F.L., and Lam, J.R.: 1986 Environ. Hlth Perpec. 65, 125.Google Scholar
  25. Harrison, S.E., and Klaverkamp, J.F.: 1989 Environ. Toxicol. Chem. 8, 87.Google Scholar
  26. Heilmaier, H.E., Drasch, G.A., Kretshmer, E., and Summer, K.H.: 1987 Toxicol. Lett. 38, 205.Google Scholar
  27. Hennig, H.F-KO.: 1986 Environ. Hlth Perspec. 65, 175.Google Scholar
  28. Honda, K., Tatsukawa, R. and Fujiyama, T.: 1982 Agric. Biol. Chem. 46, 3011.Google Scholar
  29. Imber, B.E., Thompson, J.A.J., and Ward, S.: 1987 Bull. Environ. Contam. Toxicol. 38, 707.Google Scholar
  30. Jenkins, K.D., and Sanders, B.M.: 1986 Environ. Hlth Perspec. 65, 205.Google Scholar
  31. Kagi, J.H.R., and Nordberg, M. (eds): 1979 Metallothionein. Proc. Ist International Meeting on Metallothionein and Other Low Molecular Weight Metal-Binding Proteins. Boston : Birkhauser Verlag.Google Scholar
  32. Karin, M., Andersen, R.D., Slater, E., Smith, K., and Herschman, H.R.: 1980 Nature, 286, 295.Google Scholar
  33. Karin, M., and Richards, R.I.: 1984 Environ. Hlth. Perspec. 54, 111.Google Scholar
  34. Karin, M.: 1985 Cell 41, 9.Google Scholar
  35. Kito, H., Tazawa, T., Ose, Y., Sato, T. and Ishikawa, T.: 1982 Comp. Biochem. Physiol. 73C(1), 129.Google Scholar
  36. Klaassen, C.D.: 1981 Toxicology 20, 275.Google Scholar
  37. Klaverkamp, J.F., and Duncan, D.A.: 1987 Environ. Toxicol. Chem. 6,275.Google Scholar
  38. Kudo, N., Yamashina, S., Waku, K.: 1986 Toxicology 40, 267.Google Scholar
  39. Lastowski-Perry, D., Otto E. and Maroni, G.: 1985 J. Biol. Chem. 260, 1527.Google Scholar
  40. Lauren, D.J., and Mc Donald, D.B.: 1985 J. Comp. Physiol. 155B, 635.Google Scholar
  41. Lauren, D.J., and Mc Donald, D.B.: 1987 Can. J. Fish. Aquat. Sci. 44, 99.Google Scholar
  42. Lauverjat, S., Ballan-Dufrangais, C, Wegnez, M.: 1989, Biol. Metals 2, 97.Google Scholar
  43. Lehman-Mc Keeman, L.D., Andrews, G.K., and Klaassen, C.D.: 1988 Toxicol. Appl. Pharmacol. 92, 1.Google Scholar
  44. Lefebvre, D.D., Miki, B.L., and Laliberté, J-F.: 1987 Biotechnology 5,1053.Google Scholar
  45. Mc Carter, J.A., Matheson, A.J., Roch, M., Olafson, R.W., and Buckley, J.T.: 1982 Comp. Biochem. Physiol. 72C, 21.Google Scholar
  46. Margoshes, M. and Vallee, B.L.: 1957 J. Am. Chem. Soc. 79, 4813.Google Scholar
  47. Minkel, D.J., Poulsen, K., Wielgus, S., Shaw, C.F. and Petering, D.H.: 1980 Biochem. J. 191, 475.Google Scholar
  48. Mokdad, R., Debec, A., and Wegnez, M.: 1987 Proc. Natl. Acad. Sci. USA, 84, 2658.Google Scholar
  49. Morita, S.: 1984 Jap. J. Pharmacol. 35, 129.Google Scholar
  50. Nemer, M., Travaglini, E.C., Rondinelli E., and D'Alonzo J.: 1984 Develop. Biol. 102, 471.Google Scholar
  51. Noël-Lambot, F., Bouquegneau, J.M., Frankenne, F., and Disteche, A.: 1980, Mar. Ecol. Prog. Ser. 2, 81.Google Scholar
  52. Nordberg, M., Nuottaniemi, I., Cherian, M.G., Nordberg, G.F., Kjellstron, T., and Garvey, J.S.: 1986 Environ. Hlth. Perspec. 65, 57.Google Scholar
  53. Oh, S.H., Deagen, J.J., Whanger, P.D., and Weswig P.H.: 1978 Am. J. Physiol. 234, E282.Google Scholar
  54. Oh, S.H., Whanger, P.D. and Deagen, J.J.: 1981 J. Toxicol. Environ. Hlth 7, 547.Google Scholar
  55. Olafson, R.W., Kearns, A., and Sim, R.G.: 1979a Comp. Biochem. Physiol. 62B, 417.Google Scholar
  56. Olafson, R.W., Sim, R.B., and Boto, K.G.: 1979b Comp. Biochem. Physiol. 62B, 407.Google Scholar
  57. Olsson, P.E., and Haux, C.: 1986 Aquat. Toxicol. 9, 231.Google Scholar
  58. Olsson, P.E., and Hogstrand, C.: 1987 J. Chromatogr. 402, 293.Google Scholar
  59. Onosaka, S., and Cherian, M.G.: 1982 Toxicology 23, 11.Google Scholar
  60. Onosaka, S., Tanaka, K., and Cherian, M.G.: 1984 Environ. Hlth. Perspec. 54, 67.Google Scholar
  61. Onosaka, S., Min, K.S., Fujita, Y., Tanaka, K., Iguchi, S., and Okada, Y.: 1988 Toxicol. 50, 27.Google Scholar
  62. Oronsaye, J.A.: 1987 Ecotoxicol. Environ. Saf. 15, 88.Google Scholar
  63. Overnell, J., and Coombs, T.L.: 1979 Biochem. J. 183, 277.Google Scholar
  64. Overnell, J., Mc Intosh, R., and Fletcher, T.C.: 1987a J. Fish. Biol. 30, 539.Google Scholar
  65. Overnell, J., Mc Intosh, R., and Fletcher, T.C.: 1987b Experentia 43, 178.Google Scholar
  66. Overnell, J., Fletcher, T.C., and Mc Intosh, R.: 1988 J. Fish. Biol. 33, 563.Google Scholar
  67. Petering, D.H., and Fowler, B.A.: 1986 Environ. Hlth. Perpec. 65, 217.Google Scholar
  68. Richards, M.P., and Cousins, R.J.: 1975 Biochem. Biophys. Res. Commun. 64, 1215.Google Scholar
  69. Richards, M.P., and Cousins, R.J.: 1976 J. Nutr. 106, 1591.Google Scholar
  70. Ridlington, J.W., Chapman, D.C., Goeger, D.E., and Whanger, P.D.: 1981 Comp. Biochem. Physiol. 70B, 93.Google Scholar
  71. Roch, M., Mc Carter, J.A., Matheson, A.T., Clark, M.J.R., and Olafson, R.W.: 1982 Can. J. Fish. Aquat Sci. 39, 1596.Google Scholar
  72. Roch, M, and Mc Carter, J.A.: 1984 Comp. Biochem. Physiol., 77C, 71.Google Scholar
  73. Roesijadi, G., Unger, M.E., and Morris, J.E.: 1988 Can. J. Fish. Aquat Sci. 45, 1257.Google Scholar
  74. Scheuhammer, A.M., Onosaka, S., Rodgers, K., and Cherian, M.G.: 1985 Can. J. Biochem. Cell. Biol. 63, 16.Google Scholar
  75. Scheuhammer, A.M., and Cherian, M.G.: 1986 Toxicol. Appl. Pharmacol. 82, 417.Google Scholar
  76. Scheuhammer, A.M.: 1988 Toxicol. Appl. Pharmacol. 41, 667.Google Scholar
  77. Siewicki, T.C., Sydlowski, J.S., and Webb, E.S.: 1983 Arch. Environ. Contam. Toxicol. 121 299.Google Scholar
  78. Suzuki, K.T., Itoh, N., Ohta, K. and Sunaga, H.: 1986 Comp. Biochem. Physiol. 83C, 253.Google Scholar
  79. Takeda, H., and Shimizu, C.: 1982 Bull. Jap. Soc. Sci. Fish. 48(5), 711.Google Scholar
  80. Thomas, D.B., Cryer, A., Solbe, J.F. De L.G., and Kay, J.: 1983 Comp. Biochem. Physiol. 76C(2), 24.Google Scholar
  81. Udom, A., and Brady, F.O.: 1980 Biochem. J. 187, 329.Google Scholar
  82. Vander Mallie, R.J., and Garvey, J.S.: 1979 J. Biol. Chem. 254(17), 8416.Google Scholar
  83. Viarengo, A., Moore, M.N., Mancinelli, G., Mazzucotelli, A., Pipe, R.K. and Farrar, S.U.: 1987 Mar. Biol. 94, 251.Google Scholar
  84. Waalkes, M.P., and Klassen, C.D.: 1985 Fund. Appl. Toxicol. 5, 473.Google Scholar
  85. Waalkes, M.P.: 1986 J. Toxicol. Environ. Hlth. 18, 301.Google Scholar
  86. Webb, M., and Cain, K.: 1982 Biochem. Pharmacol. 31(2), 137.Google Scholar
  87. Weis, P.: 1984 Mar. Environ. Res., 14, 153.Google Scholar
  88. Weser, V., Donay, F. and Rupp, H.: 1973 Febs Lett. 32(1), 71.Google Scholar
  89. Whanger, P.D. and Ridlington, J.W.: 1982 in Biological Roles of Metallothioneins, Foulkes, E.C. (ed.) ; Elsevier, North-Holland, New-York, 263.Google Scholar
  90. Whanger, P.D. and Deagen, J.T.: 1983 Environ. Res. 30,372.Google Scholar
  91. Woodall, C., Maclean, N. and Grossley, F.: 1988 Comp. Biochem. Physiol. 89c(1), 93.Google Scholar

Copyright information

© Kluwer Academic Publishers 1991

Authors and Affiliations

  • Richard P. Cosson
    • 1
  • Claude Amiard-Triquet
    • 1
  • Jean-Claude Amiard
    • 1
  1. 1.Service d'Ecotoxicologie, URA CNRS 1356, Faculté de PharmacieUniversité de NantesNantes CedexFrance

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