Human Genetics

, Volume 74, Issue 3, pp 223–229 | Cite as

Inverted Y chromosome polymorphism in the Gujerati Muslim Indian population of South Africa

  • R. Bernstein
  • A. Wadee
  • J. Rosendorff
  • A. Wessels
  • T. Jenkins
Original Investigations


An inverted Y chromosome has been found at a very high frequency in a Muslim Indian community living in the Johannesburg-Witwatersrand area of the Transvaal Province of South Africa: 8 of 141 (5.7%) retrospectively identified Indian males had an inv(Y)(p11.2q11.23) and all were of the Muslim faith. The inversion was found in 22 of 72 (30.5%) prospectively studied normal Muslim Indian males. All the carriers of the inversion were Gujarati-speakers whose families migrated to the Transvaal from the Gujerat Province of India during the first half of this century. The origins of the ancestors of the individuals with inv(Y) were traced to a small village, Kholvad, near the city of Surat, and some neighbouring villages. The polymorphic frequency of the inv(Y) has probably been produced through random genetic drift in a reproductively isolated community, maintained by strict endogamous marriage customs based on religious and linguistic affiliations. There was no indication that the inverted Y was associated with any reproductive disadvantages.


Internal Medicine Metabolic Disease Genetic Drift Indian Population Small Village 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • R. Bernstein
    • 1
  • A. Wadee
    • 2
    • 3
  • J. Rosendorff
    • 1
  • A. Wessels
    • 1
  • T. Jenkins
    • 1
  1. 1.Department of Human GeneticsSouth African Institute for Medical ResearchJohannesburgSouth Africa
  2. 2.Department of Immunology, School of PathologySouth African Institute for Medical ResearchJohannesburgSouth Africa
  3. 3.University of the WitwatersrandJohannesburgSouth Africa

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