, Volume 28, Issue 4, pp 204–207 | Cite as

Moderate intake of sucrose does not impair metabolic control in pump-treated diabetic out-patients

  • E. A. Chantelau
  • G. Gösseringer
  • G. E. Sonnenberg
  • M. Berger


The effects of dietary intake of sucrose versus the use of sodium cyclamate were studied in 10 Type 1 (insulin-dependent) diabetic patients on continuous subcutaneous insulin infusion therapy. After a 4-week run-in period, the patients were randomly assigned to a cross-over protocol with two 4-week periods during which they used sucrose or sodium-cyclamate as sweetener. During the experimental periods, 24±13 g/day sucrose and 348±270 mg/day of sodium cyclamate were consumed, respectively. Metabolic control was monitored by the patients performing blood glucose self-monitoring several times daily. Bi-weekly, all patients were followed-up in our outpatient clinic. Mean daily blood glucose concentrations as well as the average daily insulin dose did not differ between the three experimental periods. HbAIc-levels, serum lipids and body weight remained unchanged and within the normal ranges throughout the study. Thus, moderate dietary intake of sucrose did not affect metabolic control in these normal weight, near-normoglycaemic, normolipidaemic, pump-treated Type 1 diabetic patients during a 1-month period. Whether similar conclusions apply to less well controlled diabetic patients remains to be seen.

Key words

Type 1 diabetes sucrose diet metabolic control 


  1. 1.
    Bantle JP, Laine DC, Castle GW, Thomas JW, Hoogwerf BJ, Goetz FC (1983) Postprandial glucose and insulin responses to meals containing different carbohydrates in normal and diabetic subjects. N Engl J Med 309: 7–12Google Scholar
  2. 2.
    Slama G, Haardt MJ, Jean-Joseph P, Costagliola D, Giocolea I, Bornet F, Elgrably F, Tchobroutsky G (1984) Sucrose taken during mixed meal has no additional hyperglycaemic action over isocaloric amounts of starch in well controlled diabetics. Lancet 2: 122–4Google Scholar
  3. 3.
    Editorial (1978) The policy of the European Association for the Study of Diabetes on human investigation. Diabetologia 15: 431–432Google Scholar
  4. 4.
    Sonnenberg GE, Chantelau EA, Berger M (1982) Routine treatment of insulin dependent diabetes mellitus with continuous subcutaneous insulin infusion. In: Skyler JS (ed) Insulin update 1982. Excerpta Medica, Amsterdam Princeton, pp 97–110Google Scholar
  5. 5.
    Chantelau EA, Sonnenberg GE, Best F, Heding LG, Berger M (1984) Target fasting glycaemia for pump-treated type-I diabetics. Klin Wochenschr 62: 328–330Google Scholar
  6. 6.
    Chantelau EA, Bockholt M, Lie KT, Broermann C, Sonnenberg GE, Berger M (1983) Diet and pump-treated diabetes: a long-term follow-up. Diabete Metab (Paris) 9: 277–282Google Scholar
  7. 7.
    Joint FAO/WHO Expert Committee on Food Additives (1982) Evaluation of certain food additives and contaminants. World Health Organization, Technical Report Series No. 683, Geneva, SwitzerlandGoogle Scholar
  8. 8.
    Pudel V, Schlaf G, Tischner G, Jansen J (1982) Läßt sich individuelle Ernährungsinformation standardisieren? Ernährungs-Umschau 29: 390–395Google Scholar
  9. 9.
    Flückiger R, Winterhalter K (1976) In vitro synthesis of haemoglobin AIc. FEBS Lett 71: 356–363Google Scholar
  10. 10.
    Berchtold P, Berger M, Jörgens V, Daweke C, Chantelau EA, Zimmermann H (1981) Cardiovascular risk factors and HDL-cholesterol levels in obesity. Int J Obes 5: 1–10Google Scholar
  11. 11.
    Nuttall FQ (1983) Diet and the diabetic patients. Diabetes Care 6: 197–207Google Scholar
  12. 12.
    Crapo PA, Olefsky JM (1983) Food fallacies and blood sugar. New Engl J Med 309: 44–45Google Scholar
  13. 13.
    Jenkins DJA, Wolever TMS, Taylor RH, Barker H, Fielden H, Baldwin JM, Bowling AC, Newman HC, Jenkins AL, Goff AV (1981) Glycaemic index of foods: a physiological basis for carbohydrate exchange. Am J Clin Nutr 34: 362–366Google Scholar
  14. 14.
    Jenkins DJA, Wolever TMS, Jenkins AL, Thorne JM, Lee R, Kalmusky J, Reichert R, Wong GS (1983) The glycaemic index of foods tested in diabetic patients: a new basis for carbohydrate exchange favouring the use of legumes. Diabetologia 24: 257–264Google Scholar
  15. 15.
    Schauberger G, Brinck UC, Guldner G, Spaethe R, Niklas L, Otto H (1977) Exchange of carbohydrates according to their effect on blood glucose. Diabetes 26: 415 (Abstract)Google Scholar
  16. 16.
    Slama G, Klein JC, Delage A, Ardila E, Lemaignen H, Papoz L, Tchobroutsky G (1981) Correlation between the nature and the amount of carbohydrate in meal intake and insulin delivery by the artificial pancreas in 24 insulin-dependent diabetics. Diabetes 30: 101–105Google Scholar
  17. 17.
    Pehling G, Tessari P, Gerich JE, Haymond MW, Service FJ, Rizza RA (1984) Abnormal meal carbohydrate disposition in insulin-dependent diabetes. Relative Contribution of endogenous glucose production and initial splanchnic uptake and effect of intensive insulin therapy. J Clin Invest 74: 985–991Google Scholar
  18. 18.
    Deutsche Gesellschaft für Ernährung (1980) Ernährungsbericht 1980. Deutsche Gesellschaft für Ernährung, Frankfurt, FRGGoogle Scholar
  19. 19.
    Sheiham A (1983) Sugars and dental decay. Lancet 1: 282–284Google Scholar
  20. 20.
    National Advisory Committee on Nutrition Education (1983) Proposals for nutritional guidelines for health education in Britain. Lancet 2: 782–785Google Scholar
  21. 21.
    Schade DS, Santiago JV, Skyler JS, Rizza RA (1983) Intensive insulin therapy. Medical Exam Publ, Excerpta Medica, Princeton, NJ, USAGoogle Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • E. A. Chantelau
    • 1
  • G. Gösseringer
    • 1
  • G. E. Sonnenberg
    • 1
  • M. Berger
    • 1
  1. 1.Department of MedicineDüsseldorf UniversityDüsseldorfFRG

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