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Human Genetics

, Volume 74, Issue 2, pp 143–154 | Cite as

Wiedemann-Beckwith syndrome: presentation of clinical and cytogenetic data on 22 new cases and review of the literature

  • M. J. Pettenati
  • J. L. Haines
  • R. R. Higgins
  • R. S. Wappner
  • C. G. Palmer
  • D. D. Weaver
Original Investigations

Summary

The main features of Wiedemann-Beckwith syndrome (WBS) include macroglossia, abdominal wall defects, visceromegaly, gigantism, hypoglycemia, ear creases, nevus flammeus, and mid-face hypoplasia. Twenty-two cases of WBS were examined clinically and cytogenetically, and compared to 226 previously reported cases. Aspects of the clinical evaluations are discussed. All individuals examined were chromosomally normal with no evidence of 11p abnormality as has been reported recently. The relevance of a possible relationship between clinical findings, chromosome abnormalities, and genes present on 11p is discussed. Transmission of this condition is most consistent with autosomal dominant inheritance with incomplete penetrance.

Keywords

Internal Medicine Metabolic Disease Abdominal Wall Clinical Evaluation Hypoglycemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • M. J. Pettenati
    • 1
  • J. L. Haines
    • 1
  • R. R. Higgins
    • 1
  • R. S. Wappner
    • 1
  • C. G. Palmer
    • 1
  • D. D. Weaver
    • 1
  1. 1.Department of Medical Genetics and PediatricsIndiana University School of MedicineIndianapolisUSA

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