Diabetologia

, Volume 19, Issue 4, pp 350–354 | Cite as

The effect of glucagon infusion on kidney function in short-term insulin-dependent juvenile diabetics

  • H. -H. Parving
  • J. Sandahl Christiansen
  • I. Noer
  • B. Tronier
  • C. E. Mogensen
Originals

Summary

Kidney function was studied in nine, metabolically well controlled, short-term insulin-dependent male diabetics before and during glucagon infusion of 4 to 5 and 8 to 10 ng/kg/min. Glomerular filtration rate, effective renal plasma flow (steadystate infusion technique, with urinary collections, using 125I-iothalamate and 131I-iodohippurate), and urinary albumin and β2-microglobulin excretion rates were measured. The mean plasma glucagon concentration increased during infusion from 254±19 pg/ ml to 440±31 pg/ml (low dose) and 730±52 pg/ml (high dose). Glomerular filtration rate increased in all subjects from 133±5 before the glucagon infusion to 141±4 with the low dose, and 148±7 ml/min/1.73 m2 with the high dose (p<0.01). The increase in glomerular filtration rate correlated with the rise in plasma glucagon concentration (r=0.67; p<0.01). Renal plasma flow increased from 530 ±21 before the glucagon infusion to 555±20 with the low dose and 572±29 ml/min/1.73 m2 with the high dose (p<0.01). Urinary β2-microglobulin excretion rate rose from 5.8±1.0 before infusion to 8.7±1.7 with the low dose, and 17.9±5.7 μg X 10-2/min with the high dose (p<0.01). Urinary albumin excretion remained unchanged during the glucagon infusion. These results suggest that glucagon may contribute to the reversible elevation of glomerular filtration rate typically found in poorly regulated insulin-dependent diabetics, but not to the moderate elevation found in well controlled diabetics.

Key words

Albumin β2-microglobulin glomerularfiltration rate glucagon insulin-dependent diabetes kidney function renal plasma flow 

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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • H. -H. Parving
    • 1
    • 2
    • 3
    • 4
  • J. Sandahl Christiansen
    • 1
    • 2
    • 3
    • 4
  • I. Noer
    • 1
    • 2
    • 3
    • 4
  • B. Tronier
    • 1
    • 2
    • 3
    • 4
  • C. E. Mogensen
    • 1
    • 2
    • 3
    • 4
  1. 1.Department of Clinical Physiology and Department of Medicine CBispebjerg HospitalDenmark
  2. 2.Department of Medicine FHerlev HospitalDenmark
  3. 3.Novo Research LaboratoriesSteno Memorial HospitalCopenhagenDenmark
  4. 4.Second University Clinic of Internal Medicine, KommunehospitaletÅrhusDenmark

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