European Journal of Clinical Pharmacology

, Volume 42, Issue 4, pp 385–388 | Cite as

Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men

  • P. Monteleone
  • M. Maj
  • L. Beinat
  • M. Natale
  • D. Kemali
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  • 162 Downloads

Summary

The effect of chronic administration of phosphatidylserine derived from brain cortex on the neuroendocrine responses to physical stress has been examined in a placebo-controlled study in 9 healthy men.

Phosphatidylserine 800 mg/d for 10 days significantly blunted the ACTH and cortisol responses to physical exercise (P=0.003 and P=0.03, respectively), without affecting the rise in plasma GH and PRL.

Physical exercise significantly increased the plasma lactate concentration both after placebo and phosphatidylserine.

The results suggest that chronic oral administration of phosphatidylserine may counteract stress-induced activation of the hypothalamo-pituitary-adrenal axis in man.

Key words

Phosphatidylserine Stress ACTH cortisol lactate growth hormone prolactin 

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References

  1. Axelrod J, Reisine TD (1984) Stress hormones: their interaction and regulation. Science 224: 452–459Google Scholar
  2. Bondar RJL, Mead DC (1974) Evaluation of glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides in the hexokinase method for determining glucose in serum. Clin Chem 20: 586–591Google Scholar
  3. Canonico PL, Scapagnini U (1989) Phosphatidylserine as a modulator of receptor-coupled signal transduction. In: Bazan NG, Horrocks LA, Toffano G (eds) Phospholipids in the nervous system: Biochemical and molecular pathology. Fidia Res Series, vol 17, Springer, Berlin Heidelberg New York, pp 11–20Google Scholar
  4. De Robertis E, Medina JH, Raskovsky S, Levi de Stein M, Wolfman C, Jerusalinsky D, Calvo D (1989) Action of in vivo phosphatidylserine on benzodiazepine and muscarinic receptors of rat brain. In: Bazan NG, Horrocks LA, Toffano G (eds) Phospholipids in the nervous system: biochemical and molecular pathology. Fidia Res Series, vol 17, Springer, Berlin Heidelberg New York, pp 35–42Google Scholar
  5. Gaillard RC, Al-Damluji S (1987) Stress and the pituitary-adrenal axis. Clin Endocrinol Metab 1: 319–354Google Scholar
  6. Hirata F, Haxelrod J (1980) Phospholipid methylation and biological signal transmission. Science 209: 1082–1090Google Scholar
  7. Monteleone P, Beinat L, Tanzillo C, Maj M, Kemali D (1990) Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans. Neuroendocrinol, 52: 243–248Google Scholar
  8. Nishizuka Y (1984) Turnover of inositol phospholipids and signal transduction. Science 225: 1375–1370Google Scholar
  9. Raese J, Patrick RL, Barchas JD (1976) Phospholipid induced activation of tyrosine hydroxylase from rat bran striatal synaptosomes. Biochem Pharmacol 25: 2245–2250Google Scholar
  10. Shinitzky M (1984) Membrane fluidity and receptor function. In: Membrane fluidity. Plenum Press, New York p 585–601Google Scholar
  11. Stockert M, Buscaglia V, De Robertis E (1989) In vivo action of phosphatidylserine, amitriptyline and stress on the binding of [3H]imipramine to membranes of the rat cerebral cortex. Eur J Pharmacol 160: 11–16Google Scholar
  12. Toffano G, Bruni A (1980) Pharmacological properties of phospholipid liposomes. Pharmacol Res Commun 12: 829–845Google Scholar
  13. Toffano G, Battistella A, Orlando P (1987) Pharmacokinetics of radiolabelled brain phosphatidylserine. Clin Trials J 24: 18–24Google Scholar
  14. Tuomisto J, Mannisto P (1985) Neurotransmitter regulation of anterior pituitary hormones. Pharmacol Rev 73: 249–332Google Scholar
  15. Vannucchi MG, Pepeu G (1987) Effect of phosphatidylserine on acetylcholine release and content in cortical slices from aging rats. Neurobiol Aging 8: 403–407Google Scholar
  16. Wheeler RP, Whittam R (1970) ATPase activity of the sodium pump needs of phosphatidylserine. Nature 225: 449–450Google Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • P. Monteleone
    • 1
  • M. Maj
    • 1
  • L. Beinat
    • 2
  • M. Natale
    • 1
  • D. Kemali
    • 1
  1. 1.Institute of Psychiatry, First Medical schoolUniversity of NaplesNaplesItaly
  2. 2.Fidia Research LaboratoriesAbano Terme (Padova)Italy

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