European Journal of Clinical Pharmacology

, Volume 40, Issue 2, pp 189–191 | Cite as

Effect of Liv.52, a herbal preparation, on absorption and metabolism of ethanol in humans

  • B. L. Chauhan
  • R. D. Kulkarni
Short Communications


In 8 social drinkers, the effect of a single dose of Liv.52 or placebo on ethanol absorption has been studied after ingestion of 30 ml whisky in 5 min. The t1/2 absorption with Liv.52 was 3.62 min, significantly less than after placebo, 6.29 min. The peak concentration after Liv.52 (49.9 mg · 100 ml−1) was significantly higher than with placebo (40.5 mg · 100 ml−1).

Whisky 120 ml consumed by regular alcohol users in 1 h, before and following 15 days of Liv.52 treatment produced significantly higher ethanol levels at 2, 3 and 4 h and significantly lower acetaldehyde levels at 3 and 4 h after Liv.52 treatment.

Liv.52 enhanced the rate of absorption of ethanol and rapidly reduced acetaldehyde levels, which may explain its hepatoprotective effect on ethanol-induced liver damage.

Key words

Liv.52 hepatoprotection alcohol social drinkers herbal preparation 


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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • B. L. Chauhan
    • 1
  • R. D. Kulkarni
    • 1
  1. 1.R and D CentreThe Himalaya Drug Co.BombayIndia

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