European Journal of Clinical Pharmacology

, Volume 40, Issue 2, pp 189–191

Effect of Liv.52, a herbal preparation, on absorption and metabolism of ethanol in humans

  • B. L. Chauhan
  • R. D. Kulkarni
Short Communications

Summary

In 8 social drinkers, the effect of a single dose of Liv.52 or placebo on ethanol absorption has been studied after ingestion of 30 ml whisky in 5 min. The t1/2 absorption with Liv.52 was 3.62 min, significantly less than after placebo, 6.29 min. The peak concentration after Liv.52 (49.9 mg · 100 ml−1) was significantly higher than with placebo (40.5 mg · 100 ml−1).

Whisky 120 ml consumed by regular alcohol users in 1 h, before and following 15 days of Liv.52 treatment produced significantly higher ethanol levels at 2, 3 and 4 h and significantly lower acetaldehyde levels at 3 and 4 h after Liv.52 treatment.

Liv.52 enhanced the rate of absorption of ethanol and rapidly reduced acetaldehyde levels, which may explain its hepatoprotective effect on ethanol-induced liver damage.

Key words

Liv.52 hepatoprotection alcohol social drinkers herbal preparation 

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References

  1. 1.
    Sherlock, Sheila (1975) Diseases of liver and biliary system, 5th edition, Blackwell, Oxford, p 449Google Scholar
  2. 2.
    Donnan S, Haskey J (1977) Alcoholism and cirrhosis of liver. Pop Trends 7: 18Google Scholar
  3. 3.
    Harinasuta U, Zimmerman HJ (1971) Alcoholism steatonecrosis: relationship between severity of hepatic disease and presence of mallory bodies in liver. Gastroenterology 60: 1036Google Scholar
  4. 4.
    Barry RC, McGivan JD (1985) Acetaldehyde alone may initiate hepatocellular damage in acute alcoholic liver disease. Gut 26: 1065Google Scholar
  5. 5.
    Sorrel MF, Tuma DJ (1987) The functional implications of acetaldehyde binding to all constituents. In: Rubin E (ed) Alcohol and cell. NY Acad Sci, NY, p 50Google Scholar
  6. 6.
    Korsten MA, Matsuzaki S, Feinman L, Leiber CS (1979) High blood acetaldehyde levels after ethanol administration — difference between alcoholic and non-alcoholic subjects. N Engl J Med 8: 386Google Scholar
  7. 7.
    Jenkins WJ, Peters TJ (1980) Selectively reduced hepatic acetaldehyde dehydrogenase in alcoholics. Lancet 628Google Scholar
  8. 8.
    Karandikar SM, Joglekar GV, Chitale GK, Balwani JH (1963) Protection by indigenous drugs against hepatotoxic effect of carbon tetrachloride — a long term study. Acta Pharmacol Toxicol 20: 274Google Scholar
  9. 9.
    Saini MR, Saini M (1985) Liv.52 protection against radiation-induced lesion in mammalian liver. Radiobiol Radiother 26: 379Google Scholar
  10. 10.
    Majumdar SM, Kulkarni RD (1977) Paracetamol-induced hepato-toxicity and protective effect of Liv.52. Ind Practit 11: 479Google Scholar
  11. 11.
    Joglekar GV, Leevy CM (1970) Effect of an indigenous drug on I.C.G. clearance and autoradiographic patterns in albino rats with experimentally induced hepatotoxicity. J Ind Med Prof 12: 74Google Scholar
  12. 12.
    Shaper AG, Wannametee G, Walker H (1988) Alcohol and mortality in British men: Explaining the ‘U’ shaped curve. Lancet 12: 1267Google Scholar
  13. 13.
    The J Gen Med (1988) 1, 1Google Scholar
  14. 14.
    Mendenhall CL, McGee J, Green ES (1980) Simple, rapid and sensitive method for the simultaneous quantitation of ethanol and acetaldehyde in biological materials using head space gas chromatography. J Chromatogr 190: 197Google Scholar
  15. 15.
    Julkunen RJK, Tannenbaum L, Baraona E, Leiber CS (1985) First pass metabolism of ethanol, an important determinant of blood levels after alcohol consumption. Alcohol 2: 437Google Scholar
  16. 16.
    Holtzman JL, Gerhard RL, Eckfeldt JH, Mottonen LR, Finley DK, Eshelman FN (1985) The effects of several weeks of ethanol consumption of ethanol kinetics in normal men and women. Clin Pharmacol Ther 38: 157Google Scholar
  17. 17.
    Karandikar SM, Dahanukar S (1983) Influence of Trikutu powder on rifampicin bioavailability. Ind Drugs 20: 402Google Scholar
  18. 18.
    William J (1984) Liver disorders in alcoholism. In: Rosalki SB (ed) Clinical chemistry of alcoholism. Livingstone, New York, p 258Google Scholar

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • B. L. Chauhan
    • 1
  • R. D. Kulkarni
    • 1
  1. 1.R and D CentreThe Himalaya Drug Co.BombayIndia

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