European Journal of Clinical Pharmacology

, Volume 39, Issue 2, pp 173–176

Variation of benzbromarone elimination in man — a population study

  • I. Walter-Sack
  • U. Gresser
  • M. Adjan
  • I. Kamilli
  • A. Ittensohn
  • J. X. de Vries
  • E. Weber
  • N. Zöllner
Originals

Summary

The plasma benzbromarone concentration-time profile in a healthy subject who retained the compound much longer than other individuals is described. The data suggested that determination of the 24 h plasma concentration of the parent drug after a single oral dose of 100 mg benzbromarone would be an appropriate procedure to determine the elimination phenotype. Based on this procedure, 148 of 153 healthy individuals (97%) in a population study were found to eliminate benzbromarone rapidly. In one subject the 24 h benzbromarone plasma concentration was very similar to the that observed in the individual who had been more fully characterized. Four participants gave intermediate results. The data are compatible with a bimodal or trimodal distribution of different benzbromarone elimination phenotypes.

Key words

Benzbromarone elimination phenotype distribution drug metabolism drug polymorphism adverse reaction 

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • I. Walter-Sack
    • 1
  • U. Gresser
    • 2
  • M. Adjan
    • 2
  • I. Kamilli
    • 2
  • A. Ittensohn
    • 1
  • J. X. de Vries
    • 1
  • E. Weber
    • 1
  • N. Zöllner
    • 2
  1. 1.Abteilung Klinische Pharmakologie der Medizinischen KlinikUniversität HeidelbergFRG
  2. 2.Medizinische PoliklinikLudwig-Maximilians-UniversitätMünchenFRG

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