Human Genetics

, Volume 81, Issue 3, pp 295–297 | Cite as

Genetic polymorphism of human urine deoxyribonuclease I

  • Koichiro Kishi
  • Toshihiro Yasuda
  • Shuichi Awazu
  • Keiko Mizuta
Short Communications

Summary

A genetic polymorphism of human urine deoxyribonuclease I (DNase I) has been detected by the technique of polyacrylamide gel isoelectric focusing (IEF-PAGE) followed by immunoblotting with anti-DNase I antibody. Family studies showed that the three common phenotypes —DNASE1 1, 1–2, and 2 — and the other four rare phenotypes — DNASE1 1–3, 2–3, 2–4, and 3–4 — represent homozygosity or heterozygosity for four autosomal codominant alleles, DNASE1*1, *2, *3, and *4. The frequencies of the DNASE1*1, DNASE1*2, DNASE1*3, and DNASE1*4 alleles in a studied Japanese population were 0.5453, 0.4396, 0.0117, and 0.0034, respectively.

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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • Koichiro Kishi
    • 1
  • Toshihiro Yasuda
    • 1
  • Shuichi Awazu
    • 1
  • Keiko Mizuta
    • 1
  1. 1.Department of Legal MedicineFukui Medical SchoolFukuiJapan

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