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Human Genetics

, Volume 72, Issue 1, pp 95–97 | Cite as

Detection and partial characterization of a variant form of cytosolic aldehyde dehydrogenase isozyme

  • R. Eckey
  • D. P. Agarwal
  • N. Saha
  • H. W. Goedde
Short Communications

Summary

A rare case of human liver cytosolic aldehyde dehydrogenase (isozyme II) variation discovered in a Chinese autopsy liver specimen is reported. While the major isozyme band was nearly absent, several additional minor bands were observed on isoelectric focusing gel. Rabbit antibodies to purified human liver ALDH II showed immunological cross-reactivity for the variant enzyme bands. The existence of additional minor bands indicates the presence of tetramer hybrid forms made up of normal and variant monomers. The observed abnormality may represent the heterozygous form of ALDH II variation. A similar variant was also detected in erythrocytes of a male Thai student.

Keywords

Human Liver Rabbit Antibody Liver Specimen Partial Characterization Hybrid Form 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • R. Eckey
    • 1
  • D. P. Agarwal
    • 1
  • N. Saha
    • 2
  • H. W. Goedde
    • 1
  1. 1.Institut für Humangenetik der UniversitätHamburg 54Federal Republic of Germany
  2. 2.Department of PhysiologyNational University of SingaporeSingapore

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