, Volume 28, Issue 3, pp 207–216 | Cite as

Demonstration of a factor in the serum of homozygotes and heterozygotes for cystic fibrosis by a non-biological technique

  • K. Altland
  • S. R. Schmidt
  • G. Kaiser
  • W. Knoche
Original Investigations


A factor has been isolated from serum of homozygotes and obligate heterozygotes for cystic fibrosis using isoelectric focusing and disc electrophoresis as analytical methods. The factor is focused within an IgG-fraction with an isoelectric point of pH 8 to 9 but differs from IgG in its lower molecular weight. It is thus similar to, if not identical with, the ciliary dyskinesia factor.


Molecular Weight Internal Medicine Cystic Fibrosis Lower Molecular Weight Metabolic Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Durch analytische isoelektrische Fokusierung und Diskelektrophorese wurde aus Serum von Homozygoten und obligat Heterozygoten für cystische Fibrose ein Faktor isoliert. Der Faktor wird in einer IgG-Fraktion mit einem isoelektrischen Punkt von pH 8-9 fokusiert und unterscheidet sich von dieser Franktion durch ein kleineres Molekulargewicht. Diese Eigenschaften sind ähnlich, wenn nicht identisch mit dene des mit biologischen Tests nachweisbaren sogenannten Cilienfaktors.


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Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • K. Altland
    • 1
  • S. R. Schmidt
    • 1
  • G. Kaiser
    • 2
  • W. Knoche
    • 1
  1. 1.Institute of Anthropology and Human GeneticsUniversity of HeidelbergHeidelbergGermany
  2. 2.Children's HospitalUniversity of HeidelbergHeidelbergGermany

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