Human Genetics

, Volume 51, Issue 1, pp 1–35 | Cite as

The Papillon-Lefèvre syndrome: Keratosis palmoplantaris with periodontopathy

Report of a case and review of the cases in the literature
  • E. Haneke
Review Articles


The Papillon-Lefèvre syndrome (PLS) is an autosomal recessive trait characterized by diffuse transgredient palmar-plantar keratosis (PPK) and premature loss of both the deciduous and permanent teeth. In most cases, the PPK is noted within the first 3 years of life. The periodontal lesions begin shortly after the start of both the primary and the permanent dentitions. The teeth are affected in the order of their eruption, exhibiting inflammation of the periodontal tissue, bleeding of the gums, pocket formation, lossening, and finally spontaneous exfoliation without showing definite signs of root resorption. After an edentulous interval, the same process begins anew shortly after the second dentition.

Ectopic intracranial calcifications, mental retardation, and increased susceptibility to infections have often been seen in PLS patients and may thus be regarded as facultative signs.


Internal Medicine Metabolic Disease Mental Retardation Permanent Tooth Periodontal Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Aita, J. A.: Neurocutaneous Diseases. Springfield/Ill.: C. C. Thomas 1966Google Scholar
  2. Album, M. M., Alloy, J.: Papillon-Lefèvre's disease. A case report. J. Dent. Child. 35, 161–163 (1968)Google Scholar
  3. d'Angelo, M.: Su alcuni casi a carattere familiare di paradontosi giovanile associata a cheratodermia palmo-plantare. Rass. Int. Stomat. Prat. 23, 111–124 (1972)Google Scholar
  4. Antaki, L.: Maladie de Papillon-Lefèvre. Bull. Soc. Fr. Dermatol. Syph. 79, 531–532 (1972)Google Scholar
  5. Arabska, B., Januszewska, W.: Przypadek zespolu Papillon-Lefèvre. Czas. Stomatol. 16, 851–856 (1963)Google Scholar
  6. Arai, R., Nagashima, M.: Papillon-Lefèvre syndrome. Jpn. J. Clin. Dermatol. 28, 815–820 (1974)Google Scholar
  7. Babiček, J.: Keratoma plantare et palmare hereditarium. Rev. Méd. Tchèque 1, 5–7 (1909)Google Scholar
  8. Bach, J. N., Levan, N. E.: Papillon-Lefèvre syndrome. Arch. Dermatol. 97, 154–158 (1968)Google Scholar
  9. Baer, P. N., Benjamin, S. D.: Periodontal Disease in Children and Adolescents, pp. 206–209. Philadelphia-Toronto: Lippincott 1974Google Scholar
  10. Barrière, Delaire: Kératodermie, type Papillon-Lefèvre. Bull. Soc. Fr. Dermatol. 65, 114–115 (1958)Google Scholar
  11. Bataille, R.: Les paradontoses de kératodermies palmo-plantaires. La maladie de Meleda. Rev. Stomatol. 54, 139–146 (1953)Google Scholar
  12. Bataille, R., Duperrat, B.: La dentition dans les kératodermies palmo-plantaires congénitales. Bull. Soc. Fr. Dermatol. Syph. 59, 121–123 (1952)Google Scholar
  13. Bejček, Z.: Hyperkeratosis palmoplantaris cum parodontosi seu morbus Papillon-Lefèvre. Cesk. Stomatol 60, 198–204 (1960)Google Scholar
  14. Bellenger, E.: Chute précoce des dents temporaires et permanentes et kératose palmo-plantaire. Paris: Thèse 1954Google Scholar
  15. Bois, P., Roux, J. F.: Kératodermie palmo-plantaire et parodontose infantile aiguë type “Papillon-Lefèvre”. Méd. Trop. (Marseille) 26, 55–58 (1966)Google Scholar
  16. Boisramé, R.: Manifestations bucco-dentaires d'acrodynie infantile chez 2 sœurs. Société d'Odonto-Stomatologie de Touraine 1948, ref.: R. Boisramé. Rev. Stomatol. (Paris) 54, 242–249 (1953)Google Scholar
  17. Boisramé, R.: Polyalvéolyse chez deux enfants atteintes d'une kératodermie palmo-plantaire. Rev. Stomatol. 54, 242–249 (1953)Google Scholar
  18. Bouyssou, M., Fourel, J.: La parodontite aiguë juvénile et le syndrome de Papillon-Lefèvre. Problème clinique, pathologique et étiologique. Acta Stomatol. Belg. 70, 71–113 (1973)Google Scholar
  19. Bravo-Piris, J., Villaron, L. G., Martinez, C., Garcia-Perez, A.: Papillon-Lefèvre syndrome: Report of two familial cases. Dermatologica 152, 168–176 (1976)Google Scholar
  20. Brownstein, M. M., Skolnik, P.: Papillon-Lefèvre syndrome. Arch. Dermatol. 106, 533–534 (1972)Google Scholar
  21. Brunsting, L. A., Kierland, R. R., Perry, H. O., Winkelmann, R. R., Muller, S. A.: Palmar plantar hyperkeratosis with periodontosis (Papillon-Lefèvre syndrome). Arch. Dermatol. 90, 330 (1964)Google Scholar
  22. Calò, E.: Rilievi clinici sulle sintomatologia orale in una osservazione di malattia di Meleda (forma Papillon-Lefèvre). Mondo Odontostomatol. 6, 1–18 (1963)Google Scholar
  23. Calò, E.: Considerazione su un caso a carattere familiare di malattia di Meleda (varietà Papillon-Lefèvre). Riv. Ital. Stomatol. 25, 539–548 (1970)Google Scholar
  24. Carvel, R. I.: Palmo-plantar hyperkeratosis and premature periodontal destructions. J. Oral Med. 24, 73–82 (1969)Google Scholar
  25. Carvel, R. I.: Hiperqueratosis palmo-plantar y destrucción periodontal prematura. Trib. Odont. (Buenos Aires) 54, 75–98 (1970)Google Scholar
  26. Coccia, C. T., McDonald, R. E., Mitchel, D. F.: Papillon-Lefèvre syndrome: Precocious periodontosis with palmar-plantar hyperkeratosis. J. Periodontol. 37, 408–414 (1966)Google Scholar
  27. Corson, E. F.: Keratosis palmaris et plantaris with dental alteration. Arch. Dermatol. Syph. 40, 639 (1939)Google Scholar
  28. Cross, G. W.: Papillon-Lefèvre syndrome. 16ème Congrès de l'ARPA internationale, Wien, 14.–21.9.1960, pp. 337–339Google Scholar
  29. Davidoff, S. M.: Die parodontale Insuffizienz bei Kindern. Dtsch. Stomatol. 9, 328–331 (1959)Google Scholar
  30. deCiola, E. G.: Papillon-Lefèvre syndrome. Report of a case. J. Dent. Child. 42, 143–145 (1975)Google Scholar
  31. Degos, R., Bazex, A., Civatte, J.: Kératodermie palmo-plantaire avec alvéolyse dentaire (type Papillon-Lefèvre). Bull. Soc. Fr. Dermatol. Syph. 82, 229 (1975)Google Scholar
  32. Degos, R., Civatte, J., Arthuis, M., Mugnier, A.: Maladie de Papillon-Lefèvre. Bull. Soc. Fr. Dermatol. Syph. 83, 249–250 (1976)Google Scholar
  33. Dekker, G., Jansen, L. H.: Periodontitis in a child with hyperkeratosis palmo-plantaris. J. Periodontol. 29, 266–271 (1958)Google Scholar
  34. Diachuk, V. V., Diachuk, N. P.: Papillon-Lefèvre syndrome in children of one family (Russian). Vopr. Okhran. Materin. Det. 22/5, 81–182 (1977)Google Scholar
  35. Djawari, D.: Deficient phagocytic function in Papillon-Lefèvre syndrome. Dermatologica 156, 189–192 (1978)Google Scholar
  36. Dosseva, D., Balcheva, E., Konstantinova, B.: Clinical, genetic and cytogenetic investigation in the Papillon-Lefèvre syndrome (Bulgarian). Stomatol. (Sofia) 54, 2–8 (1972)Google Scholar
  37. Dosseva, D., Jontscheva, A.: Das Papillon-Lefèvre-Syndrom. Zahnaerztl. Welt/Reform 84, 382–383 (1975)Google Scholar
  38. Duperrat, B., Monfort, J.: Kératodermie palmo-plantaire type Papillon-Lefèvre. Bull. Soc. Fr. Dermatol. Syph. 62, 266–267 (1955)Google Scholar
  39. El Mostehy, M. R., Abdel Aal, H., Abdel Monem Abdel Aal, M.: Papillon-Lefèvre Syndrome. Report of a case in UAR. J. Egypt. Med. Assoc. 54, 441–445 (1971)Google Scholar
  40. Farzim, I., Edalat, M.: Periodontosis with hyperkeratosis palmaris et plantaris (The Papillon-Lefèvre syndrome): A case report. J. Periodontol. 45, 316–318 (1974)Google Scholar
  41. Fourel, J.: Un syndrome parodontal. Rev. Fr. Odonto-Stomatol. (Paris) 3, 345–384 (1970)Google Scholar
  42. Gaare, A.: Periodontitis og tidlig tap av temporaere og permanente tenner hos barn med keratosis palmaris et plantaris. To kasus. Nor. Tannlaegeforen. Tid. 68, 297–301 (1958)Google Scholar
  43. Galanter, D. R., Bradford, S.: Hyperkeratosis palmoplantaris and periodontosis: The Papillon-Lefèvre syndrome. J. Periodontol. 40, 40–47 (1969)Google Scholar
  44. Gauba, M. L.: Periodontosis—A case report of an eight year old child suffering from advanced periodontosis. J. All India Dent. Assoc. 32, 131–133 (1960)Google Scholar
  45. Gedda, L., Pignatelli, A.: Cheratosi palmo-plantare e allotopa a grave malattia dentaria in due fratelli neonati. Acta Genet. Med. (Roma) 3, 133–142 (1954)Google Scholar
  46. Giansanti, J. S., Hrabak, R. P., Waldron, C. A.: Palmar plantar hyperkeratosis and concomitant periodontal destruction (Papillon-Lefèvre syndrome). Oral surgery 36, 40–48 (1973)Google Scholar
  47. Gierowska, H., Kleczkowska, H., Krukowa, A., Ramisz, W., Sokolowski, M.: Niedobór witaminy E w przebiegu zespolu Papillon-Lefèvre. Pediat. Pol. 50, 777–781 (1975)Google Scholar
  48. Ginestet, G., Jaquet, A.: La maladie de Méléda: Deux observations. Rev. Fr. Odonto-Stomatol. 6, 1463–1470 (1960)Google Scholar
  49. Gontijo, J., Loures, C. G.: Sindrome de Papillon-Lefèvre. Sessão de casos em “slides”, I. Congresso dos Dermatologistas de Lîngua Portuguesa, Rio de Janeiro, 1965Google Scholar
  50. Gorlin, R. J., Sedano, H., Anderson, V. E.: The syndrome of palmar-plantar hyperkeratosis and premature periodontal destruction of the teeth. J. Pediatr. 65, 895–908 (1964)Google Scholar
  51. Greither, A.: Keratosis palmo-plantaris mit Periodontopathie (Papillon-Lefèvre). Dermatologica 119, 248–263 (1959)Google Scholar
  52. Greither, A.: Erbliche Palmoplantarkeratosen. Hautarzt 28, 395–403 (1977)Google Scholar
  53. Groshikov, M. I., Sharova, L. P.: Ein Fall von Keratodermie und Zahnausfall (Russian). Stomatologia (Mosk.) 36, 71–72 (1957)Google Scholar
  54. Grupper, C., Gougne, B., Bermejo, D., Rambert, A.: Kératodermie de Papillon-Lefèvre. Transformation spectaculaire par RO 10-9359 et PUVA. Journées dermatologiques de Paris, March 8–10, 1979Google Scholar
  55. Gudin, R.-G., Laurendeau, P.: Lésions morphologiques maxillo-faciales dans une dysplasie ectodermique héréditaire (Mal de Méléda). Actual. Odontostomatol. (Paris) 35, 395–399 (1956)Google Scholar
  56. Hacham-Zadeh, S., Schaap, T., Cohen, M. M.: A genetic analysis of the Papillon-Lefèvre syndrome in a Jewish family from Cochin. Amer. J. Med. Genet. 2, 153–157 (1978)Google Scholar
  57. Haim, S., Munk, J.: Keratosis palmo-plantaris congenita with periodontosis, arachnodactyly and a peculiar deformity of the terminal phalanges. Br. J. Dermatol. 77, 42–54 (1965)Google Scholar
  58. Hall, R. K.: The Papillon-Lefèvre syndrome. Aust. Dent. J. 8, 185–188 (1963)Google Scholar
  59. Hamdani, M. K.: Papillon-Lefèvre syndrome. Report of two cases. Int. J. Dermatol. 12, 302–304 (1973)Google Scholar
  60. Haneke, E., Hornstein, O. P., Lex, C.: Increased susceptibility to infections in the Papillon-Lefèvre syndrome. Dermatologica 150, 283–286 (1975)Google Scholar
  61. Haneke, E., Schwarzenbach, I., Hornstein, O. P.: Spätmanifeste Acrokeratoelastoidose. Z. Hautkr. 52, 170–172 (1977)Google Scholar
  62. Harndt, E.: Parodontitis und Parodontose. München: C. Hanser-Verl. 1950Google Scholar
  63. Hawes, R. R.: Report of three patients experiencing juvenile periodontosis and early loss of teeth. J. Dent. Child. 27, 169–177 (1960)Google Scholar
  64. Herforth, A., Knolle, G., Strassburg, M.: Juvenile Parodontopathien und Hauterkrankungen. Dtsch. Zahnaerztl. Z. 28, 242–246 (1973)Google Scholar
  65. Hesse, P. G.: Keratosis palmo-plantaris Papillon-Lefèvre. Zbl. Haut. Geschl. Kr. 121, 79 (1966)Google Scholar
  66. Hickory, J. E., Schell, J., Richard, G. E.: Papillon-Lefèvre syndrome. J. oral Surg. 33, 671–672 (1975)Google Scholar
  67. Hvidberg-Hansen, J., Larsen, F. E., Kleener, J.: Dyskeratotic marginal keratoconjunctivitis in hereditary periodontopathy and hyperkeratosis. Acta Ophthalmol. [Suppl.] (Kbh.) 128, 157–161 (1974)Google Scholar
  68. Imagawa, Y., Ishikawa, J., Kawasaki, H., Matsue, I., Suzuki, F., Yoshida, H., Ozawa, A., Yamada, M.: Periodontosis in a child with hyperkeratosis palmo-plantaris hereditaria. J. Jpn. Organ. Res. Periodontol. 6, 16–25 (1964)Google Scholar
  69. Ingle, J. I.: Papillon-Lefèvre syndrome: Precocious periodontosis with associated epidermal lesions. J. Periodontol. 30, 230–237 (1959)Google Scholar
  70. Ionata, I.: Displasie dentarie nelle ipercheratosi palmo-plantari. Riv. Ital. Stomatol. 7, 305–319 (1952)Google Scholar
  71. Iusem, R.: Dos casos de grave reabsorción alveolar en la infancia. Rev. Odontol. (Buenos Aires) 33, 87–105 (1945)Google Scholar
  72. Jansen, L. H.: Le caractère héréditaire de l'hyperkératose palmo-plantaire avec paradentose (Papillon-Lefèvre). J. Genet. Hum. 5, 216–224 (1956)Google Scholar
  73. Jansen, L. H., Dekker, G.: Hyperkeratosis palmo-plantaris with periodontosis (Papillon-Lefèvre). Dermatologica 113, 207–219 (1956)Google Scholar
  74. Jorgenson, R. J., Levin, L. S., Hutcherson, S. T., Salinas, C. F.: Periodontosis in sibs. Oral Surg. 39, 396–402 (1975)Google Scholar
  75. Kaminski, A., Daitsch, J., Sirolli, V. M., Jorcansky, S.: Tres hermanos afectados de hiperqueratosis palmo-plantar con periodontosis (Papillon-Lefèvre). Bull. V Congr. Ibero-Latino-Americano de Dermatologia, D. O. Pierini (ed.), pp. 1289–1299. Buenos Aires, 24.–30.11.1963Google Scholar
  76. Kerebel, B., Clergeau-Guérithault, S., Brion, M.: Etude odontologique ultrastrucrale d'un cas de maladie de Papillon-Lefèvre. Ann. Anat. Pathol. (Paris) 20, 283–292 (1975)Google Scholar
  77. Keszthelyi, G., Kovàcs, A.: Papillon-Lefèvre-syndroma esete Fogorv. Sz. 66, 10–13 (1973)Google Scholar
  78. Knychalska-Karwan, Z., Biedowa, J., Jakób-Dolezal, K.: Parodontopatie w chorobach uwarunkowanych genetycznie. Czas. Stomatol. 26, 427–433 (1973)Google Scholar
  79. Koch, F., Kirschner, H., Ehlers, B.: Über das Papillon-Lefèvre-Syndrom (Palmar-Plantar-Hyperkeratose mit vorzeitigem Zahnausfall infolge parodontaler Destruktion des Knochens). Arch. Kinderheilkd. 177, 210–216 (1968)Google Scholar
  80. Köhler, J. A.: Parodontopathie Jugendlicher und Keratoma palmare und plantare. Forum Paradontologicum 3, 885–898 (1953)Google Scholar
  81. Kolinský, J.: Hyperkeratosis palmo-plantaris cum paradentosi. Cesk. Dermatol. 32, 328–332 (1957)Google Scholar
  82. Koppen, F.: Ein seltener Fall von jugendlicher Paradontose. Inaugural-Dissertation, Med. Fak., Tübingen, 1933Google Scholar
  83. Kralisz, W.: Zespól Papillon-Lefèvre (Opis przypadków). Czas. Stomat. 26, 839–845 (1973)Google Scholar
  84. Krebs, A.: Papillon-Lefèvre-Syndrom. Dermatologica 156, 59–63 (1978)Google Scholar
  85. Krupińska, A., Pasykowa, K.: Obraz jamy ustnej w przypadku zespolu Papillon-Lefêvrea. Czas. Stomatol. 24, 1253–1257 (1971)Google Scholar
  86. Lal, S., Ventakapathy, L., Bhargawa, I., Naik, D. N.: Papillon-Lefèvre syndrome; case report with cytogenetic study. Indian J. Dermatol. 37, 83–84 (1971)Google Scholar
  87. Lenskaya, N. A., Slepak, L. K., Stulyeva, T. A.: Papillon-Lefèvre syndrome in a two and a half-year-old child (Russian) Pediatria (Moskau) 84–85 (1975)Google Scholar
  88. Lenstrup, E., Brinch, O.: Ein ungewöhnlicher Fall von Paradontose. Zahnaerztl Rundschau 46/Paradontium 5, 101–105 (1937)Google Scholar
  89. Luczycka-Kmiecik, E.: Obserwacja przypadku z zespolem Papillon-Lefèvre od 4 do 18 roku zycia. Czas. Stomat. 31, 311–317 (1978)Google Scholar
  90. Lyuban, B. L., Mirakhmedova, D. U.: Congenital keratoderma of the palms and soles Papillon-Lefèvre (Russian). Vest. Derm. Vener. (Moskau) 9, 49–50 (1978)Google Scholar
  91. Marcard, P., Casteigt, Prabes, Marcard, A.: Syndrome de Papillon-Lefèvre et syndrome de Marfan. Bull. Soc. Fr. Dermatol. Syph. 78, 56–57 (1971)Google Scholar
  92. Martinez Lalis, R. R., López Otero, O. R., Carranza, F. A. Jr.: A case of Papillon-Lefèvre syndrome. Periodontics 3, 292–295 (1965)Google Scholar
  93. McVicar, D. N., Pearlstein, H. H.: Papillon-Lefèvre syndrome: hyperkeratosis palmoplantaris with periodontosis. Arch. Dermatol. 94, 231–232 (1966)Google Scholar
  94. Meshaka, J. M., Salamoun, Z.: A propos d'un cas de parodontolyse infantile en rapportavec une kératodermie palmo-plantaire. Rev. Dent. Liban 19, 29 (1969)Google Scholar
  95. Miller, W., Maszewska-Kuźniarz, K.: Pfzypadek dysplaziej ektodermalnej. Pediatr. Pol. 38, 841–844 (1963)Google Scholar
  96. Moynahan, E. J., Cross, G. W.: Hyperkeratosis of palms and soles and “periodontosis” (Papillon-Lefèvre syndrome). Proc. R. Soc. Med. 53, 565 (1960)Google Scholar
  97. Münch, J.: Haut-Schleimhauterkrankungen und Parodontopathien. Quintessenz 20/10, 121–123 (1969)Google Scholar
  98. Munford, A. G.: Papillon-Lefèvre syndrome—Report of 2 cases in the same family. J. Am. Dent. Assoc. 93, 121–124 (1976)Google Scholar
  99. Naik, D. N., Velou, A., Alavandar, G., Radhakrishna, B. K.: Papillon-Lefèvre syndrome. Oral Surgery 25, 19–23 (1968)Google Scholar
  100. Navarrete, F.: Sindrome de Papillon-Lefèvre. Rev. As. Dental Mexicana 27, 323 (1970)Google Scholar
  101. Navarrete, F., Vázquez-Fritz, C., Salomé Cedillo, M., Espinosa-Ayala, J.: Sindrome de Papillon-Lefèvre. Bol. Med. Hosp. Infant. (Mexico) 31, 95–99 (1974)Google Scholar
  102. Newman, M., Angel, I., Karge, H., Weiner, M., Grinenko, V., Schusterman, L.: Bacterial studies of the Papillon-Lefèvre syndrome. J Dent. Res. 56, 545 (1977)Google Scholar
  103. Nicolas, P., Haag, R.: Paradontite précoce et dyskératose palmoplantaire. Strasbourg Méd. 18, 493–499 (1967)Google Scholar
  104. Nishiyama, S.: Papillon-Lefèvre syndrome (Japanese). Nippon Rinsho 35, Suppl. 1., 1212–1213 (1977)Google Scholar
  105. Nouel, A. A., Jacobo, A. F., Bogaert, H.: Sindrome de Papillon-Lefèvre. Hiperqueratosis palmoplantar con periodontosis. Rev. Dominicana Dermatol. 4, 25–37 (1970)Google Scholar
  106. Ohkawara, A., Miura, Y., Ishikawa, J.: Papillon-Lefèvre syndrome. Arch. Dermatol. 109, 726–728 (1974)Google Scholar
  107. Orbaneja, J. G., de Castro Torres, A., Pacios, A.: Hiperqueratosis palmo-plantar con periodontosis. Acta Derm.-sif. (Madrid) 57, 293–295 (1966)Google Scholar
  108. Oszetzky, T.: Keratosis palmaris és plantarishoz társuló gyermekkori parodontosis. Fogorv. Sz. 62, 107–111 (1969)Google Scholar
  109. Owińska, B., Sielicka-Zuber, L.: Zespól Papillon-Lefèvre. Przegl. Dermatol. 61, 193–196 (1974)Google Scholar
  110. Papillon, Lefèvre, P.: Deux cas de kératodermie palmaire et plantaire symétrique familiale (Maladie de Meleda) chez le frère et la soeur, Coexistence dans les deux cas d'alterations dentaires graves. Bull. Soc. Fr. Dermatol. Syph. 31, 82–87 (1924)Google Scholar
  111. Pappalardo, G.: Su un caso di paradontolisi associata a lieve ipercheratosi palmo-plantare in un bambino di anni 3 e mezzo. Minerva Stomatol. 9, 30–33 (1959)Google Scholar
  112. Pappalardo, G.: Considerazioni su di un caso di paradontolisi associata a ipercheratosi palmoplantare ad otto anni di distanza dalla prima osservazione. Riv. Mediterr. Odontost. 7, 375–384 (1967)Google Scholar
  113. Pasyk, K., Wislocka, E., Krupińska, A.: Zmiany skorne w zespole Papillon-Lefèvrea (Hyperkeratosis palmoplantaris et periodontosis). Przegl. Dermatol. 60, 645–652 (1973)Google Scholar
  114. Perriman, A. O.: Papillon-Lefèvre syndrome. Br. Dent. J. 123, 484–488 (1967)Google Scholar
  115. Perušek, M.: Parodontopatija s keratotiěnimi spremebami na koži. Zobozdrav. Vestn. 20, 223–228 (1965)Google Scholar
  116. Petges, G., Delguel: Hyperkératose palmo-plantaire congénitale, et polyarthrite alvéolo-dentaire syppurée, précoce, récidivante, expulsive de toutes les dents temporaires et permanentes. Gaz. Hebd. Sci. Méd. (Bordeaux) 22, 348–349 (1927)Google Scholar
  117. Pfister, R.: Das Papillon-Lefèvre-Syndrom. Fortschr. Med. 83, 717–720 (1965)Google Scholar
  118. Picarelli, A.: Le paradontopatie giovanili in corso d'ipercheratosi palmo-plantare e la sindroma di Papillon-Lefèvre. Minerva Stomatol. 17, 587–601 (1968)Google Scholar
  119. Piguet, B., Coumel, C., Bonnefond-Craponne, M.: Keratodermie palmo-plantaire (type Papillon-Lefèvre). Rev. Stomatol. 70, 446–459 (1969)Google Scholar
  120. Plathner, C.-H.: Verlust bleibender Zähne durch Paradentitis marginalis chronica progressiva im Wechselgebiß. Dtsch. Zahnaerztl. Z. 6, 361–368 (1951)Google Scholar
  121. Polaczek, T.: Zmiany obrazu jamy ustney w przypadku zespolu Papillon-Lefèvre w uzebieniu mlecznym. Czas. Stomat. 31, 211–214 (1978)Google Scholar
  122. Pomposiello, I. M., Calandra, R.: Queratodermia palmoplantar con paradentosis (Papillon-Lefèvre). Arch. Argent. Dermatol. 11, 385–393 (1961)Google Scholar
  123. Pop-Nikolov, D., Lazarevska, B., Arsovski, T., Kuzmanovski, N.: Oral changes in keratosis palmo-plantaris (Macedonian). God. Zb. Med. Fak. Skopje 22, 415–424 (1976)Google Scholar
  124. Pop-Nikolov, D., Starčevié, M., Skokljev, A., Arnerié, S.: Keratosis palmo-plantaris cum parodontopathiam (Syndrome Papillon-Lefèvre). Vojnosanit. Pregl. 34, 38–40 (1977)Google Scholar
  125. Proenca, N., Rotberg, A., Todescan, J. H.: Queratose palmoplantar con periodontopatia (Papillon-Lefèvre). An. Bras. Dermat. 45, 249–254 (1970)Google Scholar
  126. Rainova, I.: Uber Insufficientia parodontalis (Parodontosis, Amphodontosis) bei Kindern. Dtsch. Stomatol. 5, 681–685 (1955)Google Scholar
  127. Rateitschak, K. H., Eberle, P.: Juvenile Parodontopathien. Schweiz. Monatsschr. Zahnheilkd. 73, 809–824 (1963)Google Scholar
  128. Ressa, P.: Cheratodermia tipo Papillon-Lefèvre associata ad ipercheratosi follicolare diffusa. 49. Nat. Congr., Soc. Ital. Dermatol. Roma, 16.–18. 12. 1968. Minerva Dermatol. 45, 195–197 (1970)Google Scholar
  129. Rink, B., Stoehr, K.: Parodontopathien im Kindesalter und Keratoma palmare et plantare. Dtsch. Stomatol. 21, 917–923 (1971)Google Scholar
  130. Romańska, K., Górkowa, H., Lenik, J.: Zespól Papillon-Lefèvre u 31/3-letniej dziewczynki. Pediatr. Pol. 48, 1019–1022 (1973)Google Scholar
  131. Rosenthal, S. L.: Periodontosis in a child resulting in exfoliation of the teeth. J. Periodontol. 22, 101–104 (1951)Google Scholar
  132. Ruben, M. P., Frankl, S. N., Wallace, S.: The histopathology of periodontal disease in children. J. Periodontol. 42, 473–484 (1971)Google Scholar
  133. Ruiz-Maldonado, R.: Palmo-plantar hyperkeratosis with periodontosis (Papillon-Lefèvre syndrome). Int. J. Dermatol. 10, 10–12 (1971)Google Scholar
  134. Schaffer, A. L., Pearlstein, H. H.: Hyperkeratosis palmoplantaris with periodontosis (Papillon-Lefèvre syndrome). Oral Surg. 24, 180–185 (1967)Google Scholar
  135. Schnyder, U. W., Klunker, W.: Erbliche Verhornungsstörungen der Haut. IV. 1.a. Keratosis palmoplantaris mit Periodontopathie. In: Hdb. Haut- u., Erg. W. VII, A. Marchionini (ed.), S. 912–913 (1966)Google Scholar
  136. Shoshan, S., Finkelstein, S., Rosenzweig, K. A.: Disc electrophoretic pattern of gingival collagen isolated from a patient with palmoplantar hyperkeratosis. J. Periodont. Res. 5, 255–258 (1970)Google Scholar
  137. Silvestrini Biavati, M., Tomasini, E.: Su di un raro caso di malattia di Meleda (Forma Papillon-Lefèvre). Ann. Stomatol. (Roma) 7, 465–483 (1958)Google Scholar
  138. Smith, P., Rosenzweig, K. A.: Seven cases of Papillon-Lefèvre syndrome. Periodontics 5, 42–46 (1967)Google Scholar
  139. Sršeň, S., Fukaldová, V., Mocik, A.: Papillonov-Lefèvreov syndróm-genetické aspekty. Cesk. Stomat. 77, 66–72 (1977)Google Scholar
  140. Stein, P.: Uber die erblichen Hyperkeratosen der Handinnenflächen und Fußsohlen unter besonderer Berücksichtigung der Hyperkeratosis palmoplantaris mit Parodontitis (Papillon-Lefèvre). Med. Diss. Freiburg i. Br., 1960Google Scholar
  141. Stevanović, D. V.: Keratoderma with periodontopathy. Dermatologica 123, 119–128 (1961)Google Scholar
  142. Thiers, H., Chanial, G.: Polykératose de Touraine. Kératodermie palmo-plantaire familiale héréditaire, avec hyperhidrose, onychogryphose, hypotrichie, dystrophie osseuse et hypoplasie dentaire. Ann. Dermatol. Syphiligr. 84, 269–277 (1957)Google Scholar
  143. Thorel, M. F.: Un cas de maladie de Méléda, variété Papillon-Lefèvre avec surdité. Bull. Soc. Fr. Dermatol. Syphiligs 71, 707–708 (1964)Google Scholar
  144. Urs, R. A. P., Thomas, S., Hoover, W.: Hyperkeratosis palmoplantaris with involvement of teeth (Papillon-Lefèvre syndrome). Indian Pediat. 13, 865–870 (1976)Google Scholar
  145. Velou, A., Naik, D. N., Lal, S.: Papillon-Lefèvre syndrome. Indian J. Dermatol. 34, 163–165 (1969)Google Scholar
  146. Van de Vijver, L. M.: La maladie de Papillon-Lefèvre dans le cadre des alvéolyses graves. Acta Stomatol. Belg. 67, 481–493 (1970)Google Scholar
  147. Verma, K. C., Chaddha, M. K., Joshi, R. K.: Papillon-Lefèvre syndrome. Int. J. Derm. 18, 146–149 (1979)Google Scholar
  148. Vissian, J., Manassero, J., Bloch, C., Vaillard, J.-C.: Kératodermie palmo-plantaire type Papillon-Lefèvre chez une fillette de 12 ans. Bull. Soc. Fr. Dermatol. Syphiligs 79, 356–358 (1972)Google Scholar
  149. Vivier, A. du: Papillon Lefèvre syndrome. Proc. R. Soc. Med. 67, 18–19 (1974)Google Scholar
  150. Wannenmacher, E.: Ursachen auf dem Gebiet der Paradentose. Zbl. Gesamt. Zahn-, Mund-, Kieferheilkd. 3, 81–96 (1938)Google Scholar
  151. Wannenmacher, E.: Ursachen auf dem Gebiet der Paradentopathien. Zbl. Gesamt. Zahn-, Mund-, Kieferheilkd. 7, 1–15 (1942)Google Scholar
  152. Weston, J. A.: The migration and differentiation of neural crest cells. Adv. Morphog. 8, 41–114 (1970)Google Scholar
  153. Weyers, H.: Die dystrophische Parodontitis im Milchgebiß als Manifestation einer ektodermalen Akropathie (parodontopathia acro-ectodermalis). Dtsch. Stomatol 7, 342–353 (1957)Google Scholar
  154. Wilson, F. M.: Papillon-Lefèvre syndrome. Report of a case. Oral Surg. 28, 488–492 (1969)Google Scholar
  155. Woods, C., Wallace, W.: A case of alveolar atrophy of unknown origin in a child. Am. J. Oral Surgery 27, 676–682 (1941)Google Scholar
  156. Yamada, M., Takeda, T.: A case of keratosis palmo-plantaris with periodontopathy (Papillon-Lefèvre's disease). (Jpn.) Acta Dermatol. (Kyoto) 61, 81–91 (1966)Google Scholar
  157. Yermolaev, I. I., Tsegelnik, L. N.: Papillon-Lefèvre syndrome. Stomatologiya (Moscow) 40, 15–17 (1961)Google Scholar
  158. Zhits, M. Z., Grebennikov, V. A., Litakova, G. I.: Case of keratoderma of the Papillon-Lefèvre type (Russian). Klin. Med. (Moskau) 55/11 129–131 (1977)Google Scholar
  159. Ziprkowski, L., Ramon, Y., Brish, M.: Hyperkeratosis palmoplantaris with periodontosis (Papillon-Lefèvre). Arch. Dermatol. 88, 207–209 (1963)Google Scholar

Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • E. Haneke
    • 1
  1. 1.Dermatologische KlinikUniversität Erlangen-NürnbergErlangenFederal Republic of Germany

Personalised recommendations