Theoretical and Applied Genetics

, Volume 47, Issue 1, pp 35–39 | Cite as

On the power of experimental designs for the detection of linkage between marker loci and quantitative loci in crosses between inbred lines

  • M. Soller
  • T. Brody
  • A. Genizi


The power of experiments aimed at detecting linkage between a quantitative locus and a marker locus, both segregating in the backross or F2 generation of a cross between two inbred lines, is examined. Given that the two lines are close to fixation for alternative alleles of both marker locus and quantitative locus, it is concluded that experiments involving a few thousand offspring should be able to detect close linkages involving quantitative loci (or groups of loci) having rather modest effects (i.e., that contribute, say, 1% of the total phenotypic variance in the F2).


Phenotypic Variance Inbred Line Marker Locus Close Linkage Modest Effect 
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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • M. Soller
    • 1
  • T. Brody
    • 1
  • A. Genizi
    • 2
  1. 1.Department of GeneticsThe Hebrew UniversityJerusalemIsrael
  2. 2.Department of StatisticsAgricultural Research OrganizationRehovotIsrael

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