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Diabetologia

, Volume 30, Issue 8, pp 601–609 | Cite as

Endothelial cell function in diabetic microangiopathy

  • M. Porta
  • M. La Selva
  • P. Molinatti
  • G. M. Molinatti
Review Article

Conclusions

Endothelial cells are directly exposed to altered concentrations of circulating metabolites in diabetes and are likely to be involved early, if not primarily, in the natural history of the chronic complications of the disease. Thus, better understanding of the mechanisms underlying endothelial dysfunction and of their possible pathogenetic relevance might help to establish a rationale on which to base prospective trials for the prevention or treatment of microangiopathy.

A word of caution should be made in warning that most data available today are derived from experiments in vitro or carried out under highly perturbed conditions in vivo and that virtually none of the methods employed has so far been standardised among different laboratories. Hence, it should come as no surprise if some results are in conflict with each other or will be refuted in the near future. Work on endothelium has only just begun and much still has to be done in this fascinating field of investigation.

Keywords

Public Health Endothelial Cell Internal Medicine Natural History Human Physiology 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • M. Porta
    • 1
  • M. La Selva
    • 1
  • P. Molinatti
    • 1
  • G. M. Molinatti
    • 1
  1. 1.Cattedre di Clinica Medica 2 ed EndocrinologiaUniversity of TurinTurinItaly

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