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European Journal of Nuclear Medicine

, Volume 12, Issue 3, pp 141–146 | Cite as

In vivo kinetics and displacement study of a carbon-11-labeled hallucinogen, N,N-[11C]dimethyltryptamine

  • Kazuhiko Yanai
  • Tatsuo Ido
  • Kiichi Ishiwata
  • Jun Hatazawa
  • Toshihiro Takahashi
  • Ren Iwata
  • Taiju Matsuzawa
Article

Abstract

The endogenous hallucinogen, N,N-dimethyltryptamine (DMT), was labeled with carbon-11 and its regional distribution in rat brain studied. [11C]DMT showed higher accumulation in the cerebral cortex, caudate putamen, and amygdaloid nuclei. Studies of the subcellular distribution of [11C]DMT revealed the specific localization in the fractions enriched with serotonin receptors only when a very low dose was injected into rats. The proportions of the radioactivity in receptor-rich fractions were greatly enhanced by pretreatment with the monoamine oxidase inhibitor, pargyline. Specific binding of [11C]DMT to serotonin receptors in dog brain was demonstrated by a positron emission tomographic study in which 5-methoxy-N,N-dimethyltryptamine caused approximately 20% displacement of the radioligand from the receptors.

Key words

[11C]Dimethyltryptamine Serotonin receptors Positron 

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • Kazuhiko Yanai
    • 1
  • Tatsuo Ido
    • 1
  • Kiichi Ishiwata
    • 1
  • Jun Hatazawa
    • 2
  • Toshihiro Takahashi
    • 1
  • Ren Iwata
    • 1
  • Taiju Matsuzawa
    • 2
  1. 1.Division of Radioisotope Research, Cyclotron and Radioisotope CenterTohoku UniversitySendaiJapan
  2. 2.Department of Radiology and Nuclear Medicine, Research Institute for Tuberculosis and CancerTohoku UniversitySendaiJapan

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