Human Genetics

, Volume 85, Issue 1, pp 130–132 | Cite as

Regional chromosomal assignment of the human mineralocorticoid receptor gene to 4q31.1

  • Norma Morrison
  • Stephen B. Harrap
  • Jeffrey L. Arriza
  • Elizabeth Boyd
  • J. Michael Connor
Short Communications

Summary

The gene for human mineralocorticoid receptor (hMR), previously mapped to chromosome 4, has been further localized to 4q31.1 by in situ hybridization using a biotinylated 3.75kb human cDNA clone encoding the primary amino acid sequence of hMR as a probe. Preliminary comparative mapping studies in orangutan (Pongo pygmaeus) suggest localization of the probe to the long arm of chromosome 3.

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References

  1. Arriza JL, Weinberger C, Cerelli G, Glaser TM, Handelin BL, Housman DE, Evans RM (1987) Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science 237:268–275Google Scholar
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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Norma Morrison
    • 1
  • Stephen B. Harrap
    • 2
  • Jeffrey L. Arriza
    • 3
  • Elizabeth Boyd
    • 1
  • J. Michael Connor
    • 1
  1. 1.Duncan Guthrie Institute of Medical GeneticsGlasgowUK
  2. 2.MRC Blood Pressure UnitWestern InfirmaryGlasgowUK
  3. 3.Gene Expression LaboratoryThe Salk Institute for Biological StudiesSan DiegoUSA

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